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Beta-glucans are soluble fibers that come from the cell walls of bacteria, fungi, yeasts, and some plants. They might lower the risk for heart disease.

Beta-glucans might prevent the body from absorbing cholesterol from food. They might also stimulate the immune system by increasing chemicals that prevent infections. The US FDA allows products containing at least 750 mg of beta-glucans to have a health claim stating that they might reduce heart disease risk.

Beta-glucans are most commonly used for heart disease and high cholesterol. They are also used for many other conditions, such as eczema and diabetes, but there is no good scientific evidence to support most of these other uses.

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When taken by mouth: Beta-glucans are commonly consumed in foods. Taking larger amounts of beta-glucans as medicine is possibly safe for up to 8-12 weeks. There have been no reported side effects from taking beta-glucans by mouth.

When applied to the skin: Beta-glucans are possibly safe when used for a short time period. They can cause skin rash in some people.

Special Precautions & Warnings:

Pregnancy and breast-feeding: There isn't enough reliable information to know if beta-glucans are safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.

Medications that decrease the immune system (Immunosuppressants)

Interaction Rating=Moderate Be cautious with this combination.

Beta glucans increase the immune system. By increasing the immune system beta glucans might decrease the effectiveness of medications that decrease the immune system.

Some medications that decrease the immune system include azathioprine (Imuran), basiliximab (Simulect), cyclosporine (Neoral, Sandimmune), daclizumab (Zenapax), muromonab-CD3 (OKT3, Orthoclone OKT3), mycophenolate (CellCept), tacrolimus (FK506, Prograf), sirolimus (Rapamune), prednisone (Deltasone, Orasone), corticosteroids (glucocorticoids), and others.

Herbs and supplements that might lower blood pressure: Beta-glucans might lower blood pressure. Taking it with other supplements that have the same effect might cause blood pressure to drop too much.

There are no known interactions with foods.

Beta-glucans that come from oats or barley have most often been used by adults in doses of 2-6 grams by mouth daily for 3-12 weeks. Beta-glucans that come from yeast have most often been used in doses of 250-500 mg by mouth daily for 4-12 weeks. Beta-glucans are also applied to the skin in creams. Speak with a healthcare provider to find out what dose or product might be best for a specific condition.

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