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Betaine anhydrous is a chemical that occurs naturally in the body. It can also be found in foods such as beets, spinach, cereals, seafood, and wine.

Betaine anhydrous helps the body to process a chemical called homocysteine. Homocysteine is involved in the normal function of many different parts of the body, including blood, bones, eyes, heart, muscles, nerves, and the brain. Betaine anhydrous prevents the buildup of homocysteine in the blood.

A specific betaine anhydrous prescription product (Cystadane) is FDA-approved for the treatment of high urine levels of homocysteine (homocystinuria). People also use non-prescription betaine anhydrous supplements for reducing blood and urine homocysteine levels, athletic performance, depression, dry mouth, and many other purposes, but there is no good scientific evidence to support most of these uses.

Don't confuse betaine anhydrous with betaine hydrochloride. These are not the same.

NatMed Pro rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, Ineffective, and Insufficient Evidence to Rate.
  • Homocystinuria.  Oral betaine anhydrous is effective at reducing plasma homocysteine levels in patients with homocystinuria associated with cystathionine beta-synthase (CBS) deficiency, 5,10-methylenetetrahydrofolate reductase (MTHFR) deficiency, or cobalamin cofactor metabolism (cbl) defect.
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  • Hyperhomocysteinemia.  Oral betaine anhydrous decreases plasma homocysteine levels in people with hyperhomocysteinemia; however, any effects on cardiovascular sequela and other clinical outcomes are unclear.
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When taken by mouth: Betaine anhydrous is likely safe when used in doses of up to 6 grams daily. Betaine anhydrous is available as an FDA-approved prescription product (Cystadane) and a dietary supplement. It's usually well-tolerated. Side effects might include nausea, stomach upset, diarrhea, and body odor.

When applied to the skin: There isn't enough reliable information to know if betaine anhydrous is safe or what the side effects might be.

Special Precautions & Warnings:

Pregnancy and breast-feeding: There isn't enough reliable information to know if betaine anhydrous is safe to use when pregnant or breast feeding. Stay on the safe side and avoid use.

Children: Betaine anhydrous is likely safe for most children when taken by mouth in doses up to 150mg/kg daily.

High cholesterol: Betaine anhydrous can increase levels of total and low-density lipoprotein (LDL or "bad") cholesterol in some people. People with high cholesterol should use betaine anhydrous cautiously.

It is not known if Betaine Anhydrous interacts with any medicines. Before taking Betaine Anhydrous, talk with your healthcare professional if you take any medications.

There are no known interactions with herbs and supplements.

There are no known interactions with foods.

Betaine anhydrous has most often been used by adults in doses of 1.25-3 grams by mouth twice daily. Betaine anhydrous is available as an FDA-approved prescription product (Cystadane) and a dietary supplement. Prescription products are standardized, meaning they contain a consistent dose of betaine anhydrous. Non-prescription products may contain more or less betaine anhydrous than indicated on the label.

Discuss the use of both prescription and non-prescription products with a healthcare provider.

2(N,N,N-trimethyl)ammonium-acetate, N,N,N-trimethylglycine, Betaína Anhidra, Betaine, Bétaïne Anhydre, Bétaïne de Glycine, Bétaïne de Glycocoll, Cystadane, Glycine Betaine, Glycocoll Betaine, Glycylbetaine, Lycine, Oxyneurine, TMG, Trimethyl Glycine, Trimethylbetaine, Trimethylglycine, Trimethylglycine Anhydre, Trimethylglycine Anhydrous.

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