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Bromelain is a group of enzymes found in pineapple juice and in the pineapple stem. People sometimes use it as a medicine.

Bromelain is used for pain, muscle soreness, burns, and many other conditions, but there is no good scientific evidence to support these uses.

Natural Medicines rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, Ineffective, and Insufficient Evidence to Rate.
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Info

Bromelain seems to cause the body to produce substances that fight pain and swelling (inflammation). Bromelain also contains chemicals that interfere with the growth of tumor cells and slow blood clotting.

When taken by mouth: Bromelain is POSSIBLY SAFE for most people when taken by mouth in appropriate amounts. Bromelain may cause some side effects, such as diarrhea and stomach and intestinal discomfort. Bromelain may also cause allergic reactions, especially in people who have other allergies. If you have allergies, be sure to check with your healthcare provider before taking bromelain.

When applied to the skin: Bromelain is POSSIBLY SAFE for most people when applied to the skin in appropriate amounts.

Special Precautions & Warnings:

Pregnancy and breast-feeding: There isn't enough reliable information to know if bromelain is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.

Allergies: You might have an allergic reaction to bromelain if you are allergic to pineapple, latex, ragweed, Echinacea, chrysanthemums, marigolds, daisies, wheat, celery, papain, carrot, fennel, cypress pollen, grass pollen, or other plants.

Surgery: Bromelain might increase the risk of bleeding during and after surgery. Stop using bromelain at least 2 weeks before a scheduled surgery.

Amoxicillin (Amoxil, Trimox)

Interaction Rating=Moderate Be cautious with this combination.

Taking bromelain might increase how much amoxicillin is in the body. Taking bromelain along with amoxicillin might increase effects and side effects of amoxicillin.

Antibiotics (Tetracycline antibiotics)

Interaction Rating=Moderate Be cautious with this combination.

Taking bromelain might increase how much antibiotic the body absorbs. Taking bromelain along with some antibiotics might increase effects and side effects of some antibiotics called tetracyclines.

Some tetracyclines include demeclocycline (Declomycin), minocycline (Minocin), and tetracycline (Achromycin).

Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs)

Interaction Rating=Moderate Be cautious with this combination.

Bromelain might slow blood clotting. Taking bromelain along with medications that also slow clotting might increase the chances of bruising and bleeding.

Some medications that slow blood clotting include aspirin, clopidogrel (Plavix), diclofenac (Voltaren, Cataflam, others), ibuprofen (Advil, Motrin, others), naproxen (Anaprox, Naprosyn, others), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, warfarin (Coumadin), and others.

Herbs and supplements that might slow blood clotting: Bromelain might slow blood clotting. Taking bromelain along with other herbs and supplements that also slow clotting might increase the chances of bruising and bleeding. Some of these products include alfalfa, angelica, aniseed, arnica, asafoetida, bladderwrack, celery, chamomile, clove, fenugreek, feverfew, garlic, ginger, horse chestnut, licorice, meadowsweet, poplar, northern and southern prickly ash, quassia, red clover, and willow.
Zinc: Metals such as zinc might slow down the activity of bromelain in the body, but there are no medical reports of this happening in people.

Potato: Potato contains a substance that might slow down bromelain's activity in the body.
Soy: Soybean contains a substance that might slow down bromelain's activity in the body.

The appropriate dose of bromelain depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for bromelain. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

Bromelaine, Bromélaïne, Bromelains, Bromelainum, Bromelin, Bromelina, Broméline, Enzyme d'Ananas, Pineapple Enzyme, Pineapple Fruit Bromelain.

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