Capsicum, also known as red pepper or chili pepper, is an herb. Its fruit is commonly applied to the skin for arthritis pain and other conditions.
The fruit of the capsicum plant contains a chemical called capsaicin. Capsaicin is what seems to help reduce pain and swelling. A particular form of capsicum causes intense eye pain and other unpleasant effects when it comes in contact with the face. This form is used in self-defence pepper sprays.
Capsicum is commonly used for nerve pain and other painful conditions. It is also used for many other purposes, including digestion problems, conditions of the heart and blood vessels, and many others, but there is no good scientific evidence for many of these uses.
- Diabetic neuropathy.  Applying a patch containing capsaicin 8% or a cream containing capsaicin 0.075% can reduce pain in diabetic neuropathy.
Login for details - Pain (chronic).  Topical cream containing capsaicin can reduce chronic pain associated with various conditions. Topical capsaicin is FDA-approved for this use.
Login for details - Postherpetic neuralgia.  A topical patch containing capsaicin can reduce postherpetic neuralgia pain, especially in patients with the lowest pain scores. Capsaicin is FDA-approved for this use.
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- Back pain.  Topical capsicum or capsaicin seems to be beneficial for reducing back pain.
Login for details - Cluster headache.  Intranasal capsaicin seems to be beneficial for preventing cluster headaches. Its effect in the treatment of cluster headache is unclear.
Login for details - Osteoarthritis.  The American College of Rheumatology (ACR) conditionally recommends topical capsaicin for knee osteoarthritis, but not for hip or hand osteoarthritis.
Login for details - Pain (acute).  Topical capsicum seems to be beneficial for reducing acute pain due to trauma.
Login for details - Perennial rhinitis.  Intranasal capsaicin in a dose of at least 0.1 mM seems to improve symptoms of perennial rhinitis. It is unclear if lower doses of capsaicin are beneficial.
Login for details - Postoperative nausea and vomiting (PONV).  Applying topical capsicum to acupoints seems to be beneficial for preventing PONV.
Login for details - Postoperative pain.  Applying topical capsicum-containing plaster to acupoints seems to be beneficial for reducing postoperative pain. It is unclear if a capsicum patch or capsaicin instillation prior to wound closure is beneficial for reducing postoperative pain.
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- Allergic rhinitis (hay fever).  It is unclear if intranasal capsaicin is beneficial for preventing allergic rhinitis symptoms.
Login for details - Athletic performance.  It is unclear if oral capsaicin is beneficial for improving athletic performance.
Login for details - Burning mouth syndrome.  It is unclear if applying topical capsaicin in the mouth is beneficial for burning mouth syndrome.
Login for details - Cancer.  It is unclear if eating more chili is beneficial for preventing mortality due to cancer.
Login for details - Cannabinoid hyperemesis syndrome (CHS).  Preliminary clinical research suggests that topical capsaicin might be beneficial for reducing symptoms of CHS.
Login for details - Cardiovascular disease (CVD).  It is unclear if eating more chili is beneficial for preventing mortality due to CVD.
Login for details - Diabetes.  It is unclear if oral capsaicin is beneficial for gestational diabetes.
Login for details - Dyslipidemia.  It is unclear if oral capsicum is beneficial for reducing lipid levels.
Login for details - Dyspepsia.  It is unclear if oral capsicum is beneficial for dyspepsia.
Login for details - Fibromyalgia.  It is unclear if oral capsicum is beneficial for fibromyalgia.
Login for details - Gastroesophageal reflux disease (GERD). Login for details
- HIV/AIDS-related peripheral neuropathy.  It is unclear if topical capsaicin is beneficial for this condition.
Login for details - Hypertension.  It is unclear if oral capsicum is beneficial for lowering blood pressure.
Login for details - Intermetatarsal neuroma.  It is unclear if injecting capsaicin into the third intermetatarsal space is beneficial for intermetatarsal neuroma.
Login for details - Irritable bowel syndrome (IBS).  It is unclear if oral capsicum is beneficial for IBS.
Login for details - Laryngitis. Login for details
- Motion sickness. Login for details
- Myofascial pain syndrome.  It is unclear if topical capsaicin is beneficial for myofascial pain syndrome.
Login for details - Neck pain.  It is unclear if topical capsaicin is beneficial for neck pain.
Login for details - Neuropathic pain. Login for details
- Obesity.  It is unclear if oral capsicum is beneficial for obesity.
Login for details - Overall mortality.  Eating chili may be beneficial for preventing mortality. It is unclear if taking capsicum supplements is beneficial for preventing overall mortality.
Login for details - Peptic ulcers.  It is unclear if oral capsicum is beneficial for peptic ulcers.
Login for details - Peripheral neuropathy.  Preliminary clinical research suggests that topical capsaicin might be beneficial for reducing peripheral neuropathy pain.
Login for details - Prurigo nodularis.  It is unclear if topical capsaicin is beneficial for prurigo nodularis.
Login for details - Sinonasal polyposis.  It is unclear if intranasal capsaicin is beneficial for sinonasal polyposis.
Login for details - Swallowing dysfunction.  Preliminary research shows that oral capsaicin might be beneficial for improving swallowing ability.
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When taken by mouth: Capsicum is likely safe when consumed in amounts typically found in food. Capsaicin, the active chemical in capsicum, is possibly safe when used short-term. Side effects can include stomach irritation, sweating, and runny nose. Capsicum is possibly unsafe to take in large doses or for long periods of time.
When applied to the skin: Lotions and creams that contain capsicum extract are likely safe for most adults. Capsaicin is approved by the FDA as an over-the-counter medication. Side effects can include skin irritation and itching. Capsicum can also be very irritating to the eyes, nose, and throat. Don't use capsicum on sensitive skin or near the eyes.
When used in the nose: Capsicum is possibly safe. But, application in the nose can be painful and cause burning pain, sneezing, watery eyes, and runny nose.
Special Precautions & Warnings:
Pregnancy: Capsicum is likely safe when applied to the skin during pregnancy. Capsicum is possibly safe when taken by mouth as a medicine during the second half of the second trimester and during the third trimester.Breastfeeding: If you are breast-feeding, using capsicum on your skin is likely safe. But it is possibly unsafe for your baby if you take capsicum by mouth. Skin problems (dermatitis) have been reported in breast-fed infants when mothers eat foods heavily spiced with capsicum peppers.
Children: Applying capsicum to the skin of children under two years of age is possibly unsafe. There isn't enough reliable information to know if it is safe for children to use capsicum by mouth as a medicine. Stay on the safe side and stick with the amounts found in foods.
Bleeding disorders: While conflicting results exist, capsicum might increase the risk of bleeding in people with bleeding disorders.
Damaged skin: Don't use capsicum on damaged or broken skin.
High blood pressure: Taking capsicum or eating a large amount of chili peppers might cause a spike in blood pressure. In theory, this might worsen the condition for people who already have high blood pressure.
Surgery: Capsicum might increase bleeding during and after surgery. Stop using capsicum at least 2 weeks before a scheduled surgery.
Medications for high blood pressure (ACE inhibitors)
Interaction Rating=Minor Be watchful with this combination.
Some medications for high blood pressure might cause a cough. There is one report of someone whose cough worsened when using a cream with capsicum along with these medications for high blood pressure. But is it not clear if this interaction is a big concern.
Some medications for high blood pressure include captopril (Capoten), enalapril (Vasotec), lisinopril (Prinivil, Zestril), ramipril (Altace), and others.
Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs)
Interaction Rating=Moderate Be cautious with this combination.
Capsicum might slow blood clotting. Taking capsicum along with medications that also slow clotting might increase the chances of bruising and bleeding.
Some medications that slow blood clotting include aspirin, clopidogrel (Plavix), diclofenac (Voltaren, Cataflam, others), ibuprofen (Advil, Motrin, others), naproxen (Anaprox, Naprosyn, others), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, warfarin (Coumadin), and others.
Theophylline
Interaction Rating=Moderate Be cautious with this combination.
Capsicum can increase how much theophylline the body can absorb. Taking capsicum along with theophylline might increase the effects and side effects of theophylline.
Herbs and supplements that might lower blood sugar: Capsicum might lower blood sugar. Taking it with other supplements with similar effects might lower blood sugar too much. Examples of supplements with this effect include aloe, bitter melon, cassia cinnamon, chromium, and prickly pear cactus.
Herbs and supplements that might slow blood clotting: Capsicum might slow blood clotting and increase the risk of bleeding. Taking it with other supplements with similar effects might increase the risk of bleeding in some people. Examples of supplements with this effect include garlic, ginger, ginkgo, nattokinase, and Panax ginseng.
Iron: There is some concern that using capsicum might reduce how much iron the body can absorb.
There are no known interactions with foods.
In adults, capsicum has been taken by mouth as extracts, chili, fermented red pepper, red pepper powder, lozenges, nectar, and capsaicin. In both adults and children, capsicum has been applied to the skin in creams, plasters, and gels. It's also used in nasal sprays and solutions. Speak with a healthcare provider to find out what type of product and dose might be best for a specific condition.
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