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Casein protein makes up about 80% of the protein found in milk. When consumed, the body breaks casein down into smaller pieces called casein peptides.
Casein peptides can also be made in the lab and used in supplements. It's sometimes called "casein hydrolysate" or "hydrolyzed casein" on labels. Some casein peptides might have effects that lower blood pressure. They might also have antiallergy effects when used instead of cow's milk.
People use casein peptides for eczema, food allergies, and being prone to allergies and allergic reactions (atopic disease). They are also used for colic, diabetes, high blood pressure, neonatal jaundice, asthma, infant development, acne, stress, and many other conditions, but there is no good evidence to support most of these uses.
Don't confuse casein peptides with casein protein. These are not the same.
- Atopic dermatitis (eczema). Consuming casein peptide as part of formula with or without breastmilk for up to 6 months reduces the risk of atopic dermatitis in infants.
Login for details - Atopic disease. Consuming casein peptide as part of formula during the first 4 months of life reduces the risk of atopic disease in infants with a family history of atopy. The benefits of casein peptide in infants without a family history of atopy is unclear.
Login for details - Food allergies. Consuming casein peptide formulas is a safe alternative to cow's milk in children with cow's milk allergy.
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- Colic. Clinical research shows that consuming casein peptides as part of formula reduces crying, short-term, in infants with colic.
Login for details - Diabetes. Consuming casein peptides with carbohydrates may be beneficial for reducing postprandial glucose and insulin levels in adults with type 2 diabetes. Casein peptides have also been evaluated for the prevention of type 1 diabetes in infants, with inconclusive results.
Login for details - Hypertension. The casein peptides isoleucine-proline-proline (IPP) and valine-proline-proline (VPP), sometimes referred to as lactotripeptides, can modestly reduce blood pressure in patients with hypertension. Lower doses given for shorter durations seem to produce greater effects, and the effects may be more pronounced in Japanese patients than in European patients.
Login for details - Neonatal jaundice. Clinical research suggests that consuming casein peptide reduces the risk of jaundice in neonates.
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- Asthma. Consuming casein peptide does not appear to reduce the risk of asthma in infants.
Login for details - Infant development. Consuming casein peptide does not appear to affect growth or development in healthy infants, or in premature or low-birth weight infants.
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- Acne. It is unclear if oral casein peptides are beneficial in patients with acne.
Login for details - Aging skin. It is unclear if oral casein peptides are beneficial in patients with aging skin.
Login for details - Anxiety. Login for details
- Athletic performance. It is unclear if oral casein peptides are beneficial for athletic performance.
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- Diarrhea. It is unclear if oral casein peptides are beneficial in patients with diarrhea.
Login for details - Epilepsy. Login for details
- Exercise-induced muscle soreness. It is unclear if oral casein peptides are beneficial in patients with exercise-induced muscle soreness.
Login for details - Fatigue. Login for details
- Hyperlipidemia. Low quality research suggests that oral casein peptides are not beneficial in patients with hyperlipidemia.
Login for details - Insomnia. It is unclear if oral casein peptides are beneficial in patients with insomnia.
Login for details - Physical performance. It is unclear if oral casein peptides are beneficial for physical performance.
Login for details - Stress. Login for details
When taken by mouth: Casein peptides are likely safe when consumed appropriately. They're usually well-tolerated.
Special Precautions & Warnings:
Pregnancy and breast-feeding: There isn't enough reliable information to know if casein peptides are safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.Infants and children: Casein peptides are likely safe for children and infants when taken by mouth appropriately. Most infants receiving casein peptide-based formulas do not experience side effects.
Milk allergy: People with milk allergy are allergic to the proteins contained in milk. They may also be allergic to fragments of milk proteins, such as casein peptides. If you have a milk allergy, it's best to avoid taking casein peptides. There are some specific casein peptide formulas that can be safely given to infants with milk allergy. These formulas are: Alimentum, Damira 2000, Frisolac Allergycare, and Nutramigen.
Surgery: Casein peptides might affect blood pressure. This might interfere with blood pressure control during and after surgery. Stop taking casein peptides at least 2 weeks before a scheduled surgery.
Medications for high blood pressure (Antihypertensive drugs)
Interaction Rating=Moderate Be cautious with this combination.
Casein peptides might lower blood pressure. Taking casein peptides along with medications that lower blood pressure might cause blood pressure to go too low. Monitor your blood pressure closely.
Herbs and supplements that might lower blood pressure: Casein peptides might lower blood pressure. Taking it with other supplements that have the same effect might cause blood pressure to drop too much. Examples of supplements with this effect include andrographis, L-arginine, niacin, and stinging nettle.
There are no known interactions with foods.
Casein peptides have most often been used by adults in doses up to 10.5 mg by mouth for 21-48 weeks. In infants and newborns, specific casein peptide formulas (Nutramigen or Progestimil, Mead Johnson) have been used for up to 18 months. Speak with a healthcare provider to find out what type of product and dose might be best for a specific condition.
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