+ Add to myCart

Casein protein makes up about 80% of the protein found in milk. When consumed, the body breaks casein down into smaller pieces called casein peptides.

Casein peptides can also be made in the lab and used in supplements. It's sometimes called "casein hydrolysate" or "hydrolyzed casein" on labels. Some casein peptides might have effects that lower blood pressure. They might also have antiallergy effects when used instead of cow's milk.

People use casein peptides for eczema, food allergies, and being prone to allergies and allergic reactions (atopic disease). They are also used for colic, diabetes, high blood pressure, neonatal jaundice, asthma, infant development, acne, stress, and many other conditions, but there is no good evidence to support most of these uses.

Don't confuse casein peptides with casein protein. These are not the same.

NatMed Pro rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, Ineffective, and Insufficient Evidence to Rate.
No data available.
  • Atopic dermatitis (eczema).  Consuming casein peptide as part of formula with or without breastmilk for up to 6 months reduces the risk of atopic dermatitis in infants.
  • Login for details

  • Atopic disease.  Consuming casein peptide as part of formula during the first 4 months of life reduces the risk of atopic disease in infants with a family history of atopy. The benefits of casein peptide in infants without a family history of atopy is unclear.
  • Login for details

  • Food allergies.  Consuming casein peptide formulas is a safe alternative to cow's milk in children with cow's milk allergy.
  • Login for details

  • Colic.  Clinical research shows that consuming casein peptides as part of formula reduces crying, short-term, in infants with colic.
  • Login for details

  • Diabetes.  Consuming casein peptides with carbohydrates may be beneficial for reducing postprandial glucose and insulin levels in adults with type 2 diabetes. Casein peptides have also been evaluated for the prevention of type 1 diabetes in infants, with inconclusive results.
  • Login for details

  • Hypertension.  The casein peptides isoleucine-proline-proline (IPP) and valine-proline-proline (VPP), sometimes referred to as lactotripeptides, can modestly reduce blood pressure in patients with hypertension. Lower doses given for shorter durations seem to produce greater effects, and the effects may be more pronounced in Japanese patients than in European patients.
  • Login for details

  • Neonatal jaundice.  Clinical research suggests that consuming casein peptide reduces the risk of jaundice in neonates.
  • Login for details

No data available.
No data available.
No data available.

When taken by mouth: Casein peptides are likely safe when consumed appropriately. They're usually well-tolerated.

Special Precautions & Warnings:

Pregnancy and breast-feeding: There isn't enough reliable information to know if casein peptides are safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.

Infants and children: Casein peptides are likely safe for children and infants when taken by mouth appropriately. Most infants receiving casein peptide-based formulas do not experience side effects.

Milk allergy: People with milk allergy are allergic to the proteins contained in milk. They may also be allergic to fragments of milk proteins, such as casein peptides. If you have a milk allergy, it's best to avoid taking casein peptides. There are some specific casein peptide formulas that can be safely given to infants with milk allergy. These formulas are: Alimentum, Damira 2000, Frisolac Allergycare, and Nutramigen.

Surgery: Casein peptides might affect blood pressure. This might interfere with blood pressure control during and after surgery. Stop taking casein peptides at least 2 weeks before a scheduled surgery.

Medications for high blood pressure (Antihypertensive drugs)

Interaction Rating=Moderate Be cautious with this combination.

Casein peptides might lower blood pressure. Taking casein peptides along with medications that lower blood pressure might cause blood pressure to go too low. Monitor your blood pressure closely.

Herbs and supplements that might lower blood pressure: Casein peptides might lower blood pressure. Taking it with other supplements that have the same effect might cause blood pressure to drop too much. Examples of supplements with this effect include andrographis, L-arginine, niacin, and stinging nettle.

There are no known interactions with foods.

Casein peptides have most often been used by adults in doses up to 10.5 mg by mouth for 21-48 weeks. In infants and newborns, specific casein peptide formulas (Nutramigen or Progestimil, Mead Johnson) have been used for up to 18 months. Speak with a healthcare provider to find out what type of product and dose might be best for a specific condition.

C12, C12 Peptide, C12 Peption, Casein Decapeptide, Casein-derived Peptide, Casein-derived Lactotripeptides, Casein Peptide, Casein Hydrolysate, Casein Phosphopeptide, Casein Protein Hydrolysate, Casein Tripeptide, Cysteine Milk Peptide, eHC, eHCP, Extensively Hydrolyzed Casein Protein, Hydrolyzed Casein, Hypotensive Peptides, Isoleucine-Proline-Proline, Lactotripeptide, Lactotripeptides, Peptide C12, Peptides de Caseine, Peptides de Caséine, Peptides Hypotenseurs, Péptidos de la Caseína, Sour Milk Extract, Sour Milk Peptides, Tripeptide de Caséine, Valine-Proline-Proline.

Information on this website is for informational use only and is not intended to replace professional medical advice, diagnosis, or treatment. While evidence-based, it is not guaranteed to be error-free and is not intended to meet any particular user’s needs or requirements or to cover all possible uses, safety concerns, interactions, outcomes, or adverse effects. Always check with your doctor or other medical professional before making healthcare decisions (including taking any medication) and do not delay or disregard seeking medical advice or treatment based on any information displayed on this website.

© TRC Healthcare 2023. All rights reserved. Use and/or distribution is permitted only pursuant to a valid license or other permission from TRC Healthcare.

trclogo Licensed from Therapeutic Research Center, LLC Copyright © 1995-2023 by Therapeutic Research Center, LLC. All Rights Reserved.