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Dimethylsulfoxide (DMSO) is a chemical. It is available as a prescription medicine and also as a dietary supplement. It can be taken by mouth, applied to the skin (used topically), or injected into the veins (used intravenously or by IV).

DMSO is used for bladder inflammation (interstitial cystitis), limb pain that usually occurs after an injury (complex regional pain syndrome), and leakage of intravenous (IV) drug from the vein into surrounding skin and tissue (extravasation). It is also used for other conditions, but there is no good scientific evidence to support most of these uses.

DMSO helps medicines get through the skin and can affect proteins, carbohydrates, fats, and water in the body.

When taken by mouth: There isn't enough reliable information to know if DMSO is safe or what the side effects might be.

When applied to the skin: Non-prescription DMSO is POSSIBLY UNSAFE. Some non-prescription DMSO products might be "industrial grade," which is not intended for human use. These products can contain impurities that can cause health issues. To make matters worse, DMSO is easily absorbed through the skin, so it carries these impurities rapidly into the body. Some side effects of taking DMSO include skin reactions, dry skin, headache, dizziness, drowsiness, nausea, vomiting, diarrhea, constipation, breathing problems, and allergic reactions. DMSO also causes a garlic-like taste and breath and body odor.

When applied inside the bladder: DMSO is LIKELY SAFE when applied into the bladder as a prescription medication. Don't use DMSO products that are not prescribed by a healthcare professional.

When given by IV: There isn't enough reliable information to know if DMSO is safe. It might cause side effects such as blood problems, weakness, and confusion.

Special Precautions & Warnings:

Pregnancy and breast-feeding: There isn't enough reliable information to know if DMSO is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.

Diabetes: There are reports that topical use of DMSO can change how insulin works in the body. If you use insulin to treat diabetes and also use DMSO, monitor your blood sugar closely. Insulin doses may need to be adjusted.

Certain blood disorders. Injecting DMSO intravenously (by IV) might cause red blood cells to break down. This might be a problem for people with certain blood disorders. DMSO might make these conditions worse.

Kidney problems: DMSO might harm the kidneys. Kidney function tests are recommended every 6 months if you use DMSO and have a kidney condition.

Liver problems: DMSO might harm the liver. If you have liver conditions and use DMSO, be sure to get liver function tests every 6 months.

Medications applied to the skin, eyes, or ears (Topical drugs)

Interaction Rating=Moderate Be cautious with this combination.

DMSO can sometimes increase how much medicine the body absorbs. Applying DMSO along with medications you put on the skin or in the eyes or ears can increase how much medicine your body absorbs. Increasing how much medicine your body absorbs might increase the effects and side effects of the medicine.

Medications given as a shot (Injectable drugs)

Interaction Rating=Moderate Be cautious with this combination.

DMSO (dimethylsulfoxide) might help the body absorb some medicines. Using DMSO and getting a shot might increase how much medicine the body absorbs and increase the effects and side effects of medications given as a shot.

Medications taken by mouth (Oral drugs)

Interaction Rating=Moderate Be cautious with this combination.

DMSO (dimethylsulfoxide) might increase how much medicine your body absorbs. Taking DMSO along with medications taken by mouth might increase how much medicine your body absorbs. Increasing how much medicine your body absorbs can increase the effects and side effects of your medicines.

There are no known interactions with herbs and supplements.

There are no known interactions with foods.

The following doses have been studied in scientific research:

APPLIED TO THE SKIN:

  • For limb pain that usually occurs after an injury (complex regional pain syndrome): Applying a cream containing 50% DMSO to the affected area has been used up to five times daily for 2-12 months.
  • For leakage of intravenous (IV) drug from the vein into surrounding skin and tissue (extravasation): A dressing containing 77% to 90% DMSO solution has been applied every 3-8 hours for up to 2 weeks.
INSIDE THE BLADDER:
  • For painful bladder syndrome (interstitial cystitis): Healthcare providers drip a DMSO solution into the bladder using a tube called a catheter. The catheter is removed and the patient is asked to hold the solution for a period of time before urinating.

Dimethylis Sulfoxidum, Dimethyl Sulfoxide, Dimethyl Sulphoxide, Dimethylsulfoxide, Diméthylsulfoxyde, Dimetilsulfóxido, DMSO, Methyl Sulphoxide, NSC-763, SQ-9453, Sulfoxyde de Diméthyl, Sulphinybismethane.

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