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Diosmin is a chemical called a flavonoid that is found in some plants. It's most commonly found in citrus fruits.
Diosmin might work by reducing swelling and restoring normal vein function. Diosmin also seems to have antioxidant effects. Diosmin is often taken with other plant flavonoids like hesperidin.
Diosmin is most often used for hemorrhoids and poor blood flow. It's also used for back pain and many other conditions, but there's no strong scientific evidence to support most of these uses.
- Chronic venous insufficiency (CVI). Oral diosmin, as part of a micronized purified flavonoid fraction, seems to be beneficial for reducing symptoms of CVI. It is unclear if oral diosmin alone is beneficial.
Login for details - Hemorrhoids. Oral diosmin, as part of a micronized purified flavonoid fraction or in combination with other compounds, seems to be beneficial for hemorrhoids.
Login for details - Venous leg ulcers. Oral diosmin, as part of a micronized purified flavonoid fraction, seems to be beneficial for venous leg ulcers.
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- Back pain. It is unclear if oral diosmin is beneficial for back pain.
Login for details - Chronic prostatitis and chronic pelvic pain syndrome (CP/CPPS). It is unclear if oral diosmin, as part of a micronized purified flavonoid fraction, is beneficial for CPPS.
Login for details - Coronary artery bypass graft (CABG) surgery. It is unclear if oral diosmin, as part of a micronized purified flavonoid fraction, is beneficial for patients undergoing CABG surgery.
Login for details - Diabetes. It is unclear if oral diosmin, as part of a micronized purified flavonoid fraction or in combination with other compounds, is beneficial for diabetes.
Login for details - Lymphedema. It is unclear if oral diosmin, as part of a micronized purified flavonoid fraction or in combination with other compounds, is beneficial for lymphedema.
Login for details - Minor bleeding. It is unclear if oral diosmin, as part of a micronized purified flavonoid fraction, is beneficial for minor bleeding.
Login for details - Ovarian hyperstimulation syndrome. It is unclear if oral diosmin is beneficial for reducing the occurrence of ovarian hyperstimulation syndrome.
Login for details - Varicose veins. It is unclear if oral diosmin, as part of a micronized purified flavonoid fraction, is beneficial for varicose veins.
Login for details - Venous thromboembolism (VTE). It is unclear if oral diosmin is beneficial for prevention of VTE.
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When taken by mouth: Diosmin is commonly consumed from citrus fruits. Diosmin supplements are possibly safe for most people when used short-term. Diosmin can cause some side effects such as stomach pain, diarrhea, dizziness, headache, and skin redness.
Special Precautions & Warnings:
Pregnancy and breast-feeding: Diosmin is commonly consumed from citrus fruits. Diosmin supplements are possibly safe to take with other flavonoids like hesperidin when pregnant or breast-feeding.Surgery: Diosmin might prolong bleeding and might increase the risk of bleeding during and after surgical procedures. Stop taking diosmin at least 2 weeks before a scheduled surgery.
Carbamazepine (Tegretol)
Interaction Rating=Moderate Be cautious with this combination.
Diosmin might decrease how quickly the body breaks down carbamazepine. Taking diosmin along with carbamazepine might increase the effects and side effects of carbamazepine.
Chlorzoxazone (Parafon Forte, Paraflex)
Interaction Rating=Moderate Be cautious with this combination.
Diosmin might decrease how quickly the body breaks down chlorzoxazone. Taking diosmin along with chlorzoxazone might increase the effects and side effects of chlorzoxazone.
Diclofenac (Voltaren, others)
Interaction Rating=Moderate Be cautious with this combination.
Diosmin might decrease how quickly the body breaks down diclofenac. Taking diosmin along with diclofenac might increase the effects and side effects of diclofenac.
Fexofenadine (Allegra)
Interaction Rating=Moderate Be cautious with this combination.
Some medications, such as fexofenadine, are moved by pumps in cells. Diosmin might affect these pumps and increase how much of some medications get absorbed by the body. This might cause more side effects from some medications, like fexofenadine.
Medications changed by the liver (Cytochrome P450 2C9 (CYP2C9) substrates)
Interaction Rating=Moderate Be cautious with this combination.
Some medications are changed and broken down by the liver. Diosmin might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.
Medications changed by the liver (Cytochrome P450 2E1 (CYP2E1) substrates)
Interaction Rating=Moderate Be cautious with this combination.
Some medications are changed and broken down by the liver. Diosmin might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.
Medications changed by the liver (Cytochrome P450 3A4 (CYP3A4) substrates)
Interaction Rating=Moderate Be cautious with this combination.
Some medications are changed and broken down by the liver. Diosmin might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.
Medications moved by pumps in cells (P-Glycoprotein Substrates)
Interaction Rating=Moderate Be cautious with this combination.
Some medications are moved in and out of cells by pumps. Diosmin might change how these pumps work and change how much medication stays in the body. In some cases, this might change the effects and side effects of a medication..
Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs)
Interaction Rating=Moderate Be cautious with this combination.
Diosmin might slow blood clotting. Taking diosmin along with medications that also slow blood clotting might increase the risk of bruising and bleeding.
Herbs and supplements that might slow blood clotting: Diosmin might slow blood clotting and increase the risk of bleeding. Taking it with other supplements with similar effects might increase the risk of bleeding in some people. Examples of supplements with this effect include garlic, ginger, ginkgo, nattokinase, and Panax ginseng.
There are no known interactions with foods.
Diosmin is commonly eaten in citrus fruits. As a supplement, it's usually taken in combination with other flavonoids, particularly hesperidin. It's most often been used by adults in doses of 450-1350 mg by mouth daily for 1-6 months. Speak with a healthcare provider to find out what dose might be best for a specific condition.
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