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Evening primrose is a plant native to North and South America. It also grows throughout Europe and parts of Asia. It has yellow flowers which open at sunset and close during the day. The oil from the seeds of evening primrose is most often used to make medicine.

Evening primrose is used for premenstrual syndrome (PMS), symptoms of menopause, arthritis, swelling, and other conditions, but there is no good scientific evidence to support its use.

In foods, the oil from evening primrose is used as a source of essential fatty acids.

In manufacturing, the oil from evening primrose is used in soaps and cosmetics.

Natural Medicines rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, Ineffective, and Insufficient Evidence to Rate.
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Info

Evening primrose oil contains gamma-linolenic acid which is an omega-6 essential fatty acid. It is involved in regulating inflammation and the immune system.

When taken by mouth: Evening primrose is LIKELY SAFE for most people when taken by mouth in doses up to 6 grams daily. It may cause mild side effects including upset stomach, nausea, diarrhea, and headache in some people.

When applied to the skin: There isn't enough reliable information to know if evening primrose is safe or what the side effects might be.

Special Precautions & Warnings:

Pregnancy and breast-feeding: Taking evening primrose by mouth is POSSIBLY SAFE during pregnancy. Taking up to 4 grams daily for up to 10 weeks during pregnancy seems to be safe. But until this is confirmed by additional research, it is best to stay on the safe side and avoid use. Taking evening primrose during the last weeks of pregnancy might delay labor. Don't use this product close to the end of pregnancy.

It is POSSIBLY SAFE to take evening primrose oil during breast-feeding, but it's best to check with your healthcare provider first.

Children: Evening primrose is LIKELY SAFE for most people when taken by mouth in doses up to 6 grams daily. It is also LIKELY SAFE when applied to the skin.

Bleeding disorders: There is a concern that evening primrose might increase the chance of bruising and bleeding. Don't use it if you have a bleeding disorder.

Epilepsy or another seizure disorder: There is a concern that taking evening primrose might make seizures more likely in some people.

Surgery: Evening primrose might increase the chance of bleeding during or after surgery. Stop using it at least 2 weeks before a scheduled surgery.

Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs)

Interaction Rating=Major Do not take this combination.

Evening primrose oil might slow blood clotting. Taking evening primrose oil along with medications that also slow clotting might increase the chances of bruising and bleeding.

Evening primrose oil contains GLA (gamma-linolenic acid). GLA is the part of evening primrose oil that might slow blood clotting.

Some medications that slow blood clotting include aspirin, clopidogrel (Plavix), diclofenac (Voltaren, Cataflam, others), ibuprofen (Advil, Motrin, others), naproxen (Anaprox, Naprosyn, others), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, warfarin (Coumadin), and others.

Medications used during surgery (Anesthesia)

Interaction Rating=Moderate Be cautious with this combination.

Evening primrose oil might interact with medications used during surgery. One person who was taking evening primrose oil and other medications had a seizure during surgery. But there isn't enough information to know if evening primrose oil or the other medications caused the seizure. Be sure to tell your doctor what natural products you are taking before having surgery. To be on the safe side, you should stop taking evening primrose oil at least 2 weeks before surgery.

Phenothiazines

Interaction Rating=Moderate Be cautious with this combination.

Taking evening primrose oil with phenothiazines might increase the risk of having a seizure in some people.

Some phenothiazines include chlorpromazine (Thorazine), fluphenazine (Prolixin), trifluoperazine (Stelazine), thioridazine (Mellaril), and others.

Herbs and supplements that might slow blood clotting: Using evening primrose along with herbs that can slow blood clotting could increase the risk of bleeding in some people. These herbs include angelica, clove, danshen, garlic, ginger, ginkgo, red clover, turmeric, and others.

There are no known interactions with foods.

The appropriate dose of evening primrose depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for evening primrose. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

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