Evening primrose is a plant native to North and South America. It also grows throughout Europe and parts of Asia. It has yellow flowers which open at sunset and close during the day. The oil from the seeds of evening primrose is most often used to make medicine.
Evening primrose is used for premenstrual syndrome (PMS), symptoms of menopause, arthritis, swelling, and other conditions, but there is no good scientific evidence to support its use.
In foods, the oil from evening primrose is used as a source of essential fatty acids.
In manufacturing, the oil from evening primrose is used in soaps and cosmetics.
- Asthma.  Oral evening primrose oil does not seem to be effective for asthma treatment.
Login for details - Mastalgia.  Oral evening primrose oil does not seem to improve symptoms in patients with mastalgia.
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- Acne. Login for details
- Alzheimer disease. Login for details
- Atopic dermatitis (eczema).  It is unclear if oral or topical evening primrose oil is beneficial for adults or children with atopic dermatitis; the available research is conflicting.
Login for details - Attention deficit-hyperactivity disorder (ADHD).  Some small clinical studies suggest that oral evening primrose oil is not beneficial in children with ADHD.
Login for details - Biliary disorders.  It is unclear if oral evening primrose oil is beneficial for patients with biliary disorders.
Login for details - Chronic fatigue syndrome (CFS).  It is unclear if oral evening primrose oil is beneficial for patients with CFS.
Login for details - Coronary heart disease (CHD). Login for details
- Developmental coordination disorder (DCD).  Oral evening primrose oil has only been evaluated in combination with other ingredients; its effect when used alone is unclear.
Login for details - Diabetes.  Oral evening primrose oil has only been evaluated in combination with other ingredients; its effect when used alone is unclear.
Login for details - Diabetic neuropathy.  It is unclear if oral evening primrose oil is beneficial for patients with diabetic neuropathy.
Login for details - Dry eye.  It is unclear if oral evening primrose oil is beneficial for patients with dry eye.
Login for details - Dyslexia.  Oral evening primrose oil has only been evaluated in combination with other ingredients; its effect when used alone is unclear.
Login for details - Endometriosis. Login for details
- Hepatitis B.  It is unclear if oral evening primrose oil is beneficial for patients with hepatitis B.
Login for details - Hyperlipidemia.  It is unclear if oral evening primrose oil is beneficial for improving lipid levels.
Login for details - Ichthyosis.  It is unclear if oral evening primrose oil is beneficial for patients with ichthyosis.
Login for details - Infant development.  It is unclear if oral evening primrose oil is beneficial for infant development.
Login for details - Intermittent claudication. Login for details
- Irritable bowel syndrome (IBS). Login for details
- Liver cancer.  It is unclear if oral evening primrose oil is beneficial for patients with liver cancer.
Login for details - Menopausal symptoms.  It is unclear if oral evening primrose oil is beneficial for reducing menopausal symptoms.
Login for details - Multiple sclerosis (MS).  It is unclear if oral evening primrose oil is beneficial for patients with MS; some research suggests that evening primrose oil may actually worsen MS.
Login for details - Obesity.  It is unclear if oral evening primrose oil is beneficial for individuals with obesity.
Login for details - Osteopenia.  Oral evening primrose oil has only been evaluated in combination with other ingredients; its effect when used alone is unclear.
Login for details - Osteoporosis. Login for details
- Parturition.  Research on the effects of evening primrose in labor is conflicting, and information on the dose used is lacking in some studies.
Login for details - Peptic ulcers. Login for details
- Polycystic ovary syndrome (PCOS).  Oral evening primrose oil has only been evaluated in combination with other ingredients; its effect when used alone is unclear.
Login for details - Pre-eclampsia.  It is unclear if oral evening primrose oil is beneficial for the prevention or treatment of pre-eclampsia.
Login for details - Premenstrual syndrome (PMS).  It is unclear if oral evening primrose oil is beneficial in patients with PMS.
Login for details - Psoriasis.  Oral evening primrose oil has only been evaluated in combination with other ingredients; its effect when used alone is unclear.
Login for details - Psoriatic arthritis.  Oral evening primrose oil has only been evaluated in combination with other ingredients; its effect when used alone is unclear.
Login for details - Raynaud syndrome.  It is unclear if oral evening primrose oil is beneficial in patients with this condition.
Login for details - Rheumatoid arthritis (RA).  It is unclear if oral evening primrose oil is beneficial in patients with RA.
Login for details - Schizophrenia.  It is unclear if oral evening primrose oil is beneficial in patients with schizophrenia.
Login for details - Sjogren syndrome.  It is unclear if oral evening primrose oil is beneficial in patients with this condition.
Login for details - Tardive dyskinesia.  It is unclear if oral evening primrose oil is beneficial in patients with tardive dyskinesia.
Login for details - Ulcerative colitis.  Oral evening primrose oil has only been evaluated in combination with other ingredients; its effect when used alone is unclear.
Login for details - Water warts.  It is unclear if topical evening primrose oil improves the resolution of water warts in children.
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Evening primrose oil contains gamma-linolenic acid which is an omega-6 essential fatty acid. It is involved in regulating inflammation and the immune system.
When taken by mouth: Evening primrose is LIKELY SAFE for most people when taken by mouth in doses up to 6 grams daily. It may cause mild side effects including upset stomach, nausea, diarrhea, and headache in some people.
When applied to the skin: There isn't enough reliable information to know if evening primrose is safe or what the side effects might be.
Special Precautions & Warnings:
Pregnancy and breast-feeding: Taking evening primrose by mouth is POSSIBLY SAFE during pregnancy. Taking up to 4 grams daily for up to 10 weeks during pregnancy seems to be safe. But until this is confirmed by additional research, it is best to stay on the safe side and avoid use. Taking evening primrose during the last weeks of pregnancy might delay labor. Don't use this product close to the end of pregnancy.It is POSSIBLY SAFE to take evening primrose oil during breast-feeding, but it's best to check with your healthcare provider first.
Children: Evening primrose is LIKELY SAFE for most people when taken by mouth in doses up to 6 grams daily. It is also LIKELY SAFE when applied to the skin.
Bleeding disorders: There is a concern that evening primrose might increase the chance of bruising and bleeding. Don't use it if you have a bleeding disorder.
Epilepsy or another seizure disorder: There is a concern that taking evening primrose might make seizures more likely in some people.
Surgery: Evening primrose might increase the chance of bleeding during or after surgery. Stop using it at least 2 weeks before a scheduled surgery.
Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs)
Interaction Rating=Major Do not take this combination.
Evening primrose oil might slow blood clotting. Taking evening primrose oil along with medications that also slow clotting might increase the chances of bruising and bleeding.
Evening primrose oil contains GLA (gamma-linolenic acid). GLA is the part of evening primrose oil that might slow blood clotting.
Some medications that slow blood clotting include aspirin, clopidogrel (Plavix), diclofenac (Voltaren, Cataflam, others), ibuprofen (Advil, Motrin, others), naproxen (Anaprox, Naprosyn, others), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, warfarin (Coumadin), and others.
Medications used during surgery (Anesthesia)
Interaction Rating=Moderate Be cautious with this combination.
Evening primrose oil might interact with medications used during surgery. One person who was taking evening primrose oil and other medications had a seizure during surgery. But there isn't enough information to know if evening primrose oil or the other medications caused the seizure. Be sure to tell your doctor what natural products you are taking before having surgery. To be on the safe side, you should stop taking evening primrose oil at least 2 weeks before surgery.
Phenothiazines
Interaction Rating=Moderate Be cautious with this combination.
Taking evening primrose oil with phenothiazines might increase the risk of having a seizure in some people.
Some phenothiazines include chlorpromazine (Thorazine), fluphenazine (Prolixin), trifluoperazine (Stelazine), thioridazine (Mellaril), and others.
Herbs and supplements that might slow blood clotting: Using evening primrose along with herbs that can slow blood clotting could increase the risk of bleeding in some people. These herbs include angelica, clove, danshen, garlic, ginger, ginkgo, red clover, turmeric, and others.
There are no known interactions with foods.
The appropriate dose of evening primrose depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for evening primrose. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.
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