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Feverfew (Tanacetum parthenium) is a plant native to Asia Minor and the Balkans. Feverfew dried leaves, fresh leaves, and extracts are used in medicine.

Feverfew leaves contain many different chemicals, including one called parthenolide. Parthenolide, as well as other chemicals in feverfew, might help decrease migraine headaches.

People most commonly use feverfew for migraine headaches. People also use feverfew for itching, tension headache, and many other conditions, but there is no good scientific evidence to support these uses.

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When taken by mouth: Dried feverfew leaf or feverfew extract is likely safe when taken for up to 4 months. Side effects might include upset stomach, heartburn, diarrhea, constipation, bloating, and vomiting.

Chewing the fresh leaves of feverfew is possibly unsafe. It can cause mouth sores, swelling of the mouth, and loss of taste.

Special Precautions & Warnings:

Pregnancy: Feverfew is possibly unsafe when taken by mouth during pregnancy. There is concern that it might cause early contractions and miscarriage. Don't use feverfew if you are pregnant.

Breast-feeding: There isn't enough reliable information to know if feverfew is safe to use when breast-feeding. Stay on the safe side and avoid use.

Bleeding disorders: Feverfew might slow blood clotting. Taking feverfew could increase the risk of bleeding in some people. Until more is known, use feverfew cautiously if you have a bleeding disorder.

Allergy to ragweed and related plants: Feverfew might cause an allergic reaction in people who are sensitive to the Asteraceae/Compositae plant family. This includes ragweed, chrysanthemums, marigolds, daisies, and many others. If you have allergies, be sure to check with your healthcare provider before taking feverfew.

Surgery: Feverfew might slow blood clotting. It might cause bleeding during and after surgery. Stop taking feverfew at least 2 weeks before a scheduled surgery.

Medications changed by the liver (Cytochrome P450 1A2 (CYP1A2) substrates)

Interaction Rating=Moderate Be cautious with this combination.

Some medications are changed and broken down by the liver.

Feverfew might decrease how quickly the liver breaks down some medications. Taking feverfew along with some medications that are broken down by the liver can increase the effects and side effects of some medications. Before taking feverfew, talk to your healthcare provider if you take any medications that are changed by the liver.

Some medications that are changed by the liver include amitriptyline (Elavil), haloperidol (Haldol), ondansetron (Zofran), propranolol (Inderal), theophylline (Theo-Dur, others), verapamil (Calan, Isoptin, others), and others.

Medications changed by the liver (Cytochrome P450 2C19 (CYP2C19) substrates)

Interaction Rating=Moderate Be cautious with this combination.

Some medications are changed and broken down by the liver.

Feverfew might decrease how quickly the liver breaks down some medications. Taking feverfew along with some medications that are broken down by the liver can increase the effects and side effects of some medications. Before taking feverfew, talk to your healthcare provider if you take any medications that are changed by the liver.

Some medications that are changed by the liver include omeprazole (Prilosec), lansoprazole (Prevacid), and pantoprazole (Protonix); diazepam (Valium); carisoprodol (Soma); nelfinavir (Viracept); and others.

Medications changed by the liver (Cytochrome P450 2C9 (CYP2C9) substrates)

Interaction Rating=Moderate Be cautious with this combination.

Some medications are changed and broken down by the liver.

Feverfew might decrease how quickly the liver breaks down some medications. Taking feverfew along with some medications that are broken down by the liver can increase the effects and side effects of some medications. Before taking feverfew, talk to your healthcare provider if you take any medications that are changed by the liver.

Some medications that are changed by the liver include diclofenac (Cataflam, Voltaren), ibuprofen (Motrin), meloxicam (Mobic), and piroxicam (Feldene); celecoxib (Celebrex); amitriptyline (Elavil); warfarin (Coumadin); glipizide (Glucotrol); losartan (Cozaar); and others.

Medications changed by the liver (Cytochrome P450 3A4 (CYP3A4) substrates)

Interaction Rating=Moderate Be cautious with this combination.

Some medications are changed and broken down by the liver.

Feverfew might decrease how quickly the liver breaks down some medications. Taking feverfew along with some medications that are broken down by the liver can increase the effects and side effects of some medications. Before taking feverfew, talk to your healthcare provider if you are taking any medications that are changed by the liver.

Some medications changed by the liver include lovastatin (Mevacor), ketoconazole (Nizoral), itraconazole (Sporanox), fexofenadine (Allegra), triazolam (Halcion), and many others.

Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs)

Interaction Rating=Moderate Be cautious with this combination.

Feverfew might slow blood clotting. Taking feverfew along with medications that also slow clotting might increase the chances of bruising and bleeding.

Some medications that slow blood clotting include aspirin, clopidogrel (Plavix), diclofenac (Voltaren, Cataflam, others), ibuprofen (Advil, Motrin, others), naproxen (Anaprox, Naprosyn, others), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, warfarin (Coumadin), and others.

Herbs and supplements that might slow blood clotting: Feverfew might slow blood clotting and increase the risk of bleeding. Taking it with other supplements with similar effects might increase the risk of bleeding in some people. Examples of supplements with this effect include garlic, ginger, ginkgo, nattokinase, and Panax ginseng.

There are no known interactions with foods.

Feverfew has most often been used by adults in doses of 50-150 mg by mouth daily for up to 4 months. Speak with a healthcare provider to find out what dose might be best for a specific condition.

Altamisa, Bachelor's Buttons, Chrysanthème Matricaire, Chrysanthemum parthenium, Chrysanthemum praealtum, Featerfoiul, Featherfew, Featherfoil, Flirtwort Midsummer Daisy, Grande Camomille, Leucanthemum parthenium, Matricaria, Matricaria eximia, Matricaria parthenium, Partenelle, Pyrèthre Doré, Pyrèthre Mousse, Pyrethrum parthenium, Santa Maria, Tanaceti Parthenii, Tanacetum Parthenium, Tanaisie Commune.

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