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Glycine is an amino acid. The body can make glycine on its own, but it is also consumed in the diet. Sources include meat, fish, dairy, and legumes.
Glycine is a building block for making proteins in the body. Glycine is also involved in transmitting chemical signals in the brain, so there's interest in using it for schizophrenia and improving memory. A typical diet contains about 2 grams of glycine daily.
People use glycine for schizophrenia, stroke, memory and thinking skills, insomnia, and many other purposes, but there is no good scientific evidence to support most of these uses.
- Schizophrenia. Oral glycine may improve negative, but not positive, symptoms of schizophrenia when used as adjunct to therapy with typical antipsychotics in patients resistant to monotherapy. However, glycine does not seem to provide additional benefit when used with clozapine.
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- 3-phosphoglycerate dehydrogenase (3-PGDH) deficiency. It is unclear if oral glycine is beneficial in patients with 3-PGDH deficiency.
Login for details - Aging. Oral glycine has only been evaluated in combination with other ingredients; its effect when used alone is unclear.
Login for details - Attention deficit-hyperactivity disorder (ADHD). Login for details
- Benign prostatic hyperplasia (BPH). Login for details
- Cognitive function. Small clinical studies suggest that oral glycine may modestly improve memory and cognitive function in some patients.
Login for details - Cystic fibrosis. It is unclear if oral glycine is beneficial in patients with cystic fibrosis.
Login for details - Gout. Oral glycine has only been evaluated in combination with other ingredients; its effect when used alone is unclear.
Login for details - Insomnia. Small clinical studies suggest that oral glycine may modestly improve sleep quality and daytime feelings of fatigue in patients with poor sleep quality or a restricted sleep duration.
Login for details - Isovaleric acidemia. Login for details
- Metabolic syndrome. Login for details
- Obesity. Oral glycine has only been evaluated in combination with other ingredients; its effect when used alone is unclear.
Login for details - Overactive bladder. It is unclear if oral glycine is beneficial in patients with overactive bladder.
Login for details - Physical performance. Oral glycine has only been evaluated in combination with other ingredients; its effect when used alone is unclear.
Login for details - Stroke. It is unclear if sublingual glycine is beneficial in patients with acute ischemic stroke.
Login for details - Venous leg ulcers. Topical glycine has only been evaluated in combination with other ingredients; its effect when used alone is unclear.
Login for details - Wound healing. Login for details
When taken by mouth: Glycine is possibly safe for most people when taken in doses up to 6 grams daily for 4 weeks. It's usually well-tolerated. Some people might have mild side effects such as stomach upset.
When applied to the skin: There isn't enough reliable information to know if glycine is safe or what the side effects might be.
Special Precautions & Warnings:
Pregnancy and breast-feeding: There isn't enough reliable information to know if glycine is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.Clozapine (Clozaril)
Interaction Rating=Moderate Be cautious with this combination.
Clozapine is used to help treat schizophrenia. Taking glycine along with clozapine might decrease the effects of clozapine. It is not clear why this interaction occurs. Do not take glycine if you are taking clozapine.
There are no known interactions with herbs and supplements.
There are no known interactions with foods.
Glycine has most often been used by adults in doses of 3 grams by mouth daily for up to 24 weeks. Speak with a healthcare provider to find out what dose might be best for a specific condition.
Acide Aminoacétique, Acide Amino-Acétique, Aminoacetic Acid, Athenon, Free Base Glycine, G Salt, Glicina, Glycine de Base Libre, Glycocoll, Glycosthene, Iconyl, L-Glycine, Monazol.
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