Grape

Grapes are the fruit of grapevines. Vitis vinifera and Vitis labrusca are two common grapevine species. Vitis labrusca is commonly known as Concord grape. The whole fruit, skin, leaves, and seed of the grape plant are used as medicine.

Grape is used for poor circulation that can cause the legs to swell (chronic venous insufficiency or CVI) or for eye stress. Various grape products are also commonly used for diseases of the heart and blood vessels, other eye problems, gastrointestinal health, and many other conditions. But there is no good scientific evidence to support these uses.

Grape contains flavonoids, which can have antioxidant effects, lower the levels of low density lipoproteins (LDLs, or "bad cholesterol"), relax blood vessels, and reduce the risk of coronary heart disease. The antioxidants in grape might help to prevent heart disease and have other potentially beneficial effects. Red grape varieties provide more antioxidants than white or blush grape varieties.

Grape leaf might reduce inflammation and have astringent effects. In other words, grape leaf seems to be able to draw tissue together, which could help stop bleeding and diarrhea. These properties appear to be greatest in the red leaves.

When taken by mouth: Grape is LIKELY SAFE when consumed in amounts commonly found in foods.

It is POSSIBLY SAFE to take the fruit of the grape plant, or the extract of the fruit, leaf, or seed, in medicinal amounts. Grape seed extracts and grape fruit extracts have been used safely in studies for up to 12 months. A grape leaf extract has been used safely in studies for up to 12 weeks. Eating large quantities of grapes, dried grapes, raisins, or sultanas might cause diarrhea. Some people have allergic reactions to grapes and grape products. Some other potential side effects include stomach upset, indigestion, nausea, vomiting, cough, dry mouth, and headache.

When applied to the skin: Grape seed oil is POSSIBLY SAFE when applied to the skin for up to 3 weeks. There isn't enough reliable information to know if other parts of grape are safe when applied to the skin.

Special Precautions & Warnings:

The following doses have been studied in scientific research:

ADULTS
BY MOUTH:

• For poor circulation that can cause the legs to swell (chronic venous insufficiency or CVI): A standardized red vine grape extract knows as AS 195 360 mg or 720 mg once daily for 6 to 12 weeks has been used.

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