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Hydroxymethylbutyrate (HMB) is a chemical that is made when the body breaks down leucine. Leucine is an amino acid, one of the building blocks of protein.

HMB might promote muscle growth. It can be found naturally in small amounts in grapefruit, alfalfa, and catfish. It's also naturally made in the body.

People use HMB for building muscle or preventing age-related muscle loss. It's also used for athletic performance, muscle loss due to HIV/AIDS, muscle strength, obesity, and many other purposes, but there is no good scientific evidence to support these uses.

NatMed Pro rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, Ineffective, and Insufficient Evidence to Rate.
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  • Sarcopenia.  Oral HMB seems to increase muscle mass and may attenuate muscle loss in older adults. However, it may not offer additional benefit when used in conjunction with exercise.
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No data available.
No data available.

When taken by mouth: HMB is possibly safe. Doses of up to 3 grams daily for up to one year have been used safely.

Special Precautions & Warnings:

Pregnancy and breast-feeding: There isn't enough reliable information to know if HMB is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.

It is not known if Hydroxymethylbutyrate (HMB) interacts with any medicines. Before taking Hydroxymethylbutyrate (HMB), talk with your healthcare professional if you take any medications.

There are no known interactions with herbs and supplements.

There are no known interactions with foods.

HMB and a calcium salt of HMB (Ca-HMB) have most often been used by adults in doses of 2.4-3 grams by mouth daily. Speak with a healthcare provider to find out what type of product and dose might be best for a specific condition.

Beta-hydroxy-beta-methylbutyrate, B-Hydroxy B-Methylbutyrate Monohydreate, Beta-Hydroxy-Beta-Methylbutyric Acid, Calcium B-Hydroxy B-Methylbutyrate Monohydrate, Calcium HMB, Hidroximetilbutirato, HMB, HMB de Calcium, Hydroxyméthylbutyrate, Hydroxymethyl Butyrate, Hydroxyméthyl Butyrate.

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