Lactobacillus species are probiotics ("good" bacteria) normally found in human digestive and urinary tracts. They can be consumed for diarrhea and "gut health."
"Good" bacteria such as Lactobacillus can help the body break down food, absorb nutrients, and fight off "bad" organisms that might cause diseases. Lactobacillus is sometimes added to fermented foods like yogurt and is also found in dietary supplements.
Lactobacillus is most commonly used for diarrhea, including infectious diarrhea and diarrhea in people taking antibiotics. Some people also use lactobacillus for general digestion problems, irritable bowel syndrome (IBS), colic in infants, and many other conditions that involve the stomach and bowel. But there is no good scientific evidence to support many of these uses. There is also no good evidence to support using lactobacillus for COVID-19.
- Abdominal pain.  Oral L. reuteri seems to reduce abdominal pain in children 4 years and up. It is unclear if any species are beneficial in adults.
Login for details - Allergic rhinitis (hay fever).  Oral lactobacillus seems to improve some symptoms of allergic rhinitis in adults and children. It is unclear if taking oral lactobacillus during pregnancy reduces the likelihood of the child developing allergic rhinitis.
Login for details - Antibiotic-associated diarrhea.  Oral lactobacillus, alone or in combination with other probiotics, seems to reduce the risk of antibiotic-associated diarrhea (AAD) in adults and children.
Login for details - Atopic dermatitis (eczema).  Oral lactobacillus, alone or in combination with other probiotics, seems to be beneficial for the treatment of atopic dermatitis in infants and children and for preventing atopic dermatitis when taken by the infant. It is unclear if taking oral lactobacillus during pregnancy or when breastfeeding is beneficial for preventing atopic dermatitis in infants and children.
Login for details - Atopic disease.  Taking oral L. rhamnosus GG during pregnancy and when breastfeeding, or giving it to the infant, seems to prevent atopic disease in infants and children. It is unclear if other species are beneficial.
Login for details - Bacterial vaginosis.  Most clinical research shows that intravaginal application of various lactobacillus strains may be helpful for the TREATMENT of bacterial vaginosis. Additionally, certain species of lactobacillus, intravaginally and orally, have demonstrated benefit for the PREVENTION of bacterial vaginosis.
Login for details - Colic.  Oral L. reuteri seems to be beneficial for colic. It is unclear if other species are beneficial.
Login for details - Constipation.  Oral lactobacillus seems to be beneficial for functional constipation.
Login for details - Diarrhea.  Oral lactobacillus seems to be beneficial for the prevention of acute diarrhea in children. However, it is unclear if oral lactobacillus is beneficial for the treatment of acute diarrhea in children or the prevention of acute diarrhea in adults.
Login for details - Helicobacter pylori.  In combination with most standard therapies, oral lactobacillus seems to improve H. pylori eradication. It is unclear if oral lactobacillus reduces the adverse effects associated with these standard therapies.
Login for details - Hypercholesterolemia.  Oral lactobacillus seems to be modestly beneficial for lowering cholesterol levels.
Login for details - Oral mucositis.  L. brevis lozenges seem to be beneficial for preventing moderate to severe oral mucositis.
Login for details - Respiratory tract infections.  Oral lactobacillus, alone or in combination with other probiotics, seems to prevent respiratory tract infections in children and most adults. It is unclear if lactobacillus prevents respiratory tract infections in older adults in long-term care.
Login for details - Rheumatoid arthritis (RA).  Oral lactobacillus seems to be beneficial for RA.
Login for details - Travelers' diarrhea.  Oral lactobacillus seems to be beneficial for the prevention of travelers' diarrhea.
Login for details - Ulcerative colitis.  When used in combination with standard treatment, oral lactobacillus alone or in combination with other probiotics seems to improve remission rates. However, it is unclear if oral lactobacillus prevents symptom relapse.
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- Clostridium difficile infection.  Oral lactobacillus does not seem to be beneficial for C. difficile infection prevention or recurrence.
Login for details - Crohn disease.  Oral lactobacillus does not seem to be beneficial for preventing a relapse of this condition.
Login for details - Exercise-induced respiratory infections.  Oral lactobacillus does not seem to be beneficial for preventing respiratory infections related to exercise.
Login for details - Vaginal candidiasis.  Oral or intravaginal lactobacillus does not seem to be beneficial for the prevention of vaginal candidiasis. It is unclear if intravaginal lactobacillus is beneficial in vaginal candidiasis treatment.
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- Acne.  Oral lactobacillus has only been evaluated in combination with other ingredients; its effect when used alone is unclear.
Login for details - Age-related cognitive decline.  It is unclear if oral lactobacillus is beneficial for age-related cognitive decline.
Login for details - Aging skin.  It is unclear if oral lactobacillus is beneficial for aging skin.
Login for details - Asthenopia (eye strain).  It is unclear if oral lactobacillus is beneficial for asthenopia.
Login for details - Asthma.  It is unclear if oral lactobacillus is beneficial for asthma.
Login for details - Bipolar disorder.  Oral lactobacillus has only been evaluated in combination with other ingredients; its effect when used alone is unclear.
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- Canker sores.  It is unclear if oral lactobacillus or lactobacillus lozenges are beneficial for canker sore prevention or treatment.
Login for details - Chemotherapy-induced diarrhea.  It is unclear if oral lactobacillus is beneficial for preventing chemotherapy-induced diarrhea.
Login for details - Child development.  Oral lactobacillus has only been evaluated in combination with other ingredients; its effect when used alone is unclear.
Login for details - Cholestasis.  Oral lactobacillus has only been evaluated in combination with other ingredients; its effect when used alone is unclear.
Login for details - Cognitive function.  It is unclear if oral lactobacillus improves cognitive function in young adults.
Login for details - Cognitive impairment.  It is unclear if oral lactobacillus is beneficial for cognitive impairment.
Login for details - Common cold.  It is unclear if oral lactobacillus is beneficial for the common cold.
Login for details - Critical illness (trauma).  It is unclear if oral lactobacillus is beneficial for critical illness.
Login for details - Cystic fibrosis.  It is unclear if oral lactobacillus is beneficial for cystic fibrosis.
Login for details - Dental caries.  It is unclear if oral lactobacillus is beneficial for dental caries prevention.
Login for details - Dental plaque.  It is unclear if oral lactobacillus is beneficial for dental plaque prevention.
Login for details - Depression.  Oral lactobacillus has only been evaluated in combination with other ingredients; its effect when used alone is unclear.
Login for details - Diabetes.  Oral lactobacillus seems to be beneficial for the treatment of gestational diabetes, although it is unclear if it is beneficial for treatment of type 2 diabetes. Oral lactobacillus is unlikely to be beneficial for the prevention of gestational diabetes and may actually be harmful during pregnancy.
Login for details - Diverticulitis.  It is unclear if oral lactobacillus is beneficial for diverticulitis.
Login for details - Fractures.  It is unclear if oral lactobacillus is beneficial for the healing of fractures.
Login for details - Genital herpes.  It is unclear if intravaginal lactobacillus is beneficial for genital herpes.
Login for details - Gingivitis.  It is unclear if oral lactobacillus is beneficial for gingivitis.
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- Group B streptococcal colonization.  It is unclear if oral lactobacillus is beneficial for reducing the rate of vaginal group B streptococcal (GBS) colonization.
Login for details - Hypertension.  It is unclear if oral lactobacillus is beneficial for lowering blood pressure.
Login for details - Hypertriglyceridemia.  It is unclear if oral lactobacillus is beneficial for hypertriglyceridemia.
Login for details - Influenza.  It is unclear if oral lactobacillus is beneficial for influenza.
Login for details - Irritable bowel syndrome (IBS).  Some research shows that certain species of lactobacillus, as well as a specific combination product (VSL#3, sold as Visbiome by ExeGi Pharma), may be beneficial for IBS. However, it is unclear whether other species are beneficial.
Login for details - Lactose intolerance.  It is unclear if oral lactobacillus is beneficial for lactose intolerance.
Login for details - Low birth weight.  It is unclear if oral lactobacillus is beneficial for improving outcomes in very low birth weight (VLBW) infants.
Login for details - Lyme disease. Login for details
- Mastitis.  It is unclear if oral lactobacillus is beneficial for mastitis.
Login for details - Metabolic syndrome.  It is unclear if oral lactobacillus is beneficial for metabolic syndrome.
Login for details - Necrotizing enterocolitis (NEC).  Some evidence shows that taking lactobacillus as part of multi-strain probiotics is beneficial for NEC prevention. However, it is unclear if oral lactobacillus itself is beneficial for NEC.
Login for details - Nonalcoholic fatty liver disease (NAFLD).  Oral lactobacillus has only been evaluated in combination with other ingredients; its effect when used alone is unclear.
Login for details - Obesity.  It is unclear if oral lactobacillus is beneficial for weight loss.
Login for details - Oropharyngeal candidiasis.  Oral lactobacillus has only been evaluated in combination with other ingredients; its effect when used alone is unclear.
Login for details - Otitis media.  It is unclear if oral lactobacillus is beneficial for otitis media prevention.
Login for details - Periodontitis.  It is unclear if oral lactobacillus is beneficial for periodontitis.
Login for details - Polymorphous light eruption (PMLE).  Oral lactobacillus has only been evaluated in combination with other ingredients; its effect when used alone is unclear.
Login for details - Polycystic ovary syndrome (PCOS).  Oral lactobacillus has only been evaluated in combination with other ingredients; its effect when used alone is unclear.
Login for details - Pouchitis.  Oral lactobacillus has only been evaluated in combination with other ingredients; its effect when used alone is unclear.
Login for details - Prematurity.  Oral lactobacillus has only been evaluated in combination with other ingredients; its effect when used alone is unclear.
Login for details - Prostatitis.  It is unclear if oral lactobacillus is beneficial for prostatitis.
Login for details - Radiation-induced diarrhea.  Oral lactobacillus has only been evaluated in combination with other ingredients; its effect when used alone is unclear.
Login for details - Rotaviral diarrhea.  The evidence for the use of lactobacillus in the treatment of rotaviral diarrhea in children is conflicting.
Login for details - Short bowel syndrome. Login for details
- Small intestinal bacterial overgrowth (SIBO).  It is unclear if oral lactobacillus is beneficial for the treatment or prevention of SIBO.
Login for details - Stress.  It is unclear if oral lactobacillus is beneficial for stress.
Login for details - Urinary tract infections (UTIs).  It is unclear if oral or intravaginal lactobacillus is beneficial for the prevention or treatment of UTIs.
Login for details - Ventilator-associated pneumonia (VAP).  It is unclear if oral lactobacillus is beneficial for VAP.
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When taken by mouth: Lactobacillus is likely safe. Side effects are usually mild and most often include intestinal gas or bloating.
When applied to the vagina: Lactobacillus is likely safe.
Special Precautions & Warnings:
Pregnancy and breast-feeding: Lactobacillus is possibly safe when taken by mouth appropriately while pregnant and breast-feeding.Children: Lactobacillus is likely safe when taken by mouth appropriately in children.
Central lines: Infections of the blood have been reported in people who have central lines and take lactobacillus. If you have a central line, talk with your healthcare provider before taking probiotics.
Liver scarring (cirrhosis): There is some concern that lactobacillus might cause an infection in people with cirrhosis. If you have cirrhosis, talk with your healthcare provider before taking lactobacillus.
Digestive system problems: People with serious GI disorders, such as short bowel syndrome or inflammatory bowel disease (IBD), might be more likely to develop lactobacillus infections. If you have any of these conditions, talk with your healthcare provider before taking lactobacillus.
Weakened immune system: Lactobacillus has caused blood infections in a small number of people with weakened immune systems. This includes people with HIV/AIDS or cancer, or people who are taking medications to prevent rejection of a transplanted organ. If you have a weakened immune system, talk with your healthcare provider before taking lactobacillus.
Damaged heart valves: Lactobacillus can cause an infection in the inner lining of the heart chambers and heart valve. This is extremely rare, but people with damaged heart valves might be more likely to develop this type of infection. People with damaged heart valves should stop taking probiotics before dental procedures or surgical procedures.
Antibiotic drugs
Interaction Rating=Moderate Be cautious with this combination.
Antibiotics are used to reduce harmful bacteria in the body. Antibiotics can also reduce friendly bacteria in the body. Lactobacillus is a type of friendly bacteria. Taking antibiotics along with lactobacillus can reduce the effectiveness of lactobacillus. To avoid this interaction take lactobacillus products at least 2 hours before or after antibiotics.
Medications that decrease the immune system (Immunosuppressants)
Interaction Rating=Moderate Be cautious with this combination.
Lactobacillus contains live bacteria and yeast. The immune system usually controls bacteria and yeast in the body to prevent infections. Medications that decrease the immune system can increase your chances of getting sick from bacteria and yeast. Taking lactobacillus along with medications that decrease the immune system might increase the chances of getting sick.
Some medications that decrease the immune system include azathioprine (Imuran), basiliximab (Simulect), cyclosporine (Neoral, Sandimmune), daclizumab (Zenapax), muromonab-CD3 (OKT3, Orthoclone OKT3), mycophenolate (CellCept), tacrolimus (FK506, Prograf), sirolimus (Rapamune), prednisone (Deltasone, Orasone), corticosteroids (glucocorticoids), and others.
There are no known interactions with herbs and supplements.
There are no known interactions with foods.
Lactobacillus is commonly added to fermented foods such as yogurts. It is also commonly taken in dietary supplements.
In adults, lactobacillus has most often been taken by mouth, alone or together with other probiotics, in doses of 50 million to 100 billion colony-forming units (CFUs) daily, for up to 6 months. In children, lactobacillus has most often been taken by mouth in doses of 100 million to 50 billion CFUs daily, for up to 3 months.
Acidophilus, Acidophilus Bifidus, Acidophilus Lactobacillus, L. Acidophilus, L. Amylovorus, L. Brevis, L. Bulgaricus, L. Casei, L. Casei Immunitas, L. Crispatus, L. Delbrueckii, L. Fermentum, L. Gallinarum, L. Gasseri, L. Helveticus, L. Johnsonii, L. Johnsonii LC-1, L. Lactis, L. Leichmannii, L. Paracasei, L. Pentosus, L. Plantarum, L. Reuteri, L. Rhamnosus, L. Sakei, L. Salivarius, Lacto Bacillus, Lactobacille, Lactobacilli, Lactobacilo, Lactospores, LC-1, Probiotic.
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