Maitake (Grifola frondose) is a type of mushroom. It forms large clumps on tree stumps and tree roots. It was first used in Asian traditional medicine.
Maitake mushroom grows in forests in Asia, Europe, and eastern North America. It contains chemicals that might help fight tumors, stimulate the immune system, and lower blood sugar levels.
People use maitake mushroom for enlarged ovaries with cysts, diabetes, and many other conditions, but there is no good scientific evidence to support these uses.
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- Polycystic ovary syndrome (PCOS).  Maitake mushroom may have some benefit in PCOS, but it does not appear to be as effective as clomiphene.
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When taken by mouth: Maitake mushroom is possibly safe for most people. But there isn't much information about potential side effects. Some people have reported nausea after taking maitake mushroom.
Special Precautions & Warnings:Pregnancy and breast-feeding: There isn't enough reliable information to know if maitake mushroom is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.
Surgery: Maitake mushroom might affect blood sugar levels, making blood sugar control difficult during and after surgery. Stop using maitake mushroom at least 2 weeks before a scheduled surgery.
Medications for diabetes (Antidiabetes drugs)
Interaction Rating=Moderate Be cautious with this combination.
Maitake mushroom might decrease blood sugar. Diabetes medications are also used to lower blood sugar. Taking maitake mushroom along with diabetes medications might cause your blood sugar to go too low. Monitor your blood sugar closely. The dose of your diabetes medication might need to be changed.
Some medications used for diabetes include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, pioglitazone (Actos), rosiglitazone (Avandia), chlorpropamide (Diabinese), glipizide (Glucotrol), tolbutamide (Orinase), and others.
Herbs and supplements that might lower blood pressure: Maitake mushroom might lower blood pressure. Taking it with other supplements that have the same effect might cause blood pressure to drop too much. Examples of supplements with this effect include andrographis, casein peptides, L-arginine, niacin, and stinging nettle.
Herbs and supplements that might lower blood sugar: Maitake mushroom might lower blood sugar. Taking it with other supplements with similar effects might lower blood sugar too much. Examples of supplements with this effect include aloe, bitter melon, cassia cinnamon, chromium, and prickly pear cactus.
There are no known interactions with foods.
An extract of maitake mushroom has most often been used by adults in a dose of 1-1.5 grams by mouth daily for up to 2 years. There isn't enough reliable information to know what an appropriate dose of maitake mushroom in other forms might be. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult a healthcare professional before using.
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