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Mastic is a tree. People use the sap (resin) from the trunk to make medicine.

Mastic is used for conditions such as stomach and intestinal ulcers, long-term swelling (inflammation) in the digestive tract (inflammatory bowel disease or IBD), infections, and wound healing, but there is no good scientific evidence to support these uses.

In manufacturing, mastic resin is used in the food and drink industries and in the production of chewing gum.

Natural Medicines rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, Ineffective, and Insufficient Evidence to Rate.

Mastic might help reduce stomach acid and may protect the lining of the stomach and intestine. Mastic also contains a fragrant oil which could kill bacteria and freshen the breath. In a test tube, mastic seems to fight bacteria and fungi.

When taken by mouth: Mastic is POSSIBLY SAFE for most people when taken appropriately for up to 3 months. It might cause nausea, diarrhea, or constipation in some people.

When given as a shot: A specific extract of mastic (RPh201) is POSSIBLY SAFE when given as a shot under the skin by a healthcare provider. It can cause pain and redness at the injection site.

When applied to the skin: There isn't enough reliable information to know if mastic is safe or what the side effects might be.

Special Precautions & Warnings:

Pregnancy and breast-feeding: There isn't enough reliable information to know if mastic is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.

Allergy to Schinus terebinthifolious and other Pistacia species: People who are allergic to these plants might also be allergic to mastic tree.

There are no known interactions with medications. Before taking this product, talk with your health professional if you take any medications.

There are no known interactions with herbs and supplements.

There are no known interactions with foods.

The following doses have been studied in scientific research:


  • For indigestion (dyspepsia): 350 mg of mastic gum has been taken three times daily for 3 weeks.
  • For stomach ulcers: 1-2 grams of mastic gum has been taken every day for 2-4 weeks.

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