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Palmitoylethanolamide is a chemical made from fat. It is found naturally in foods such as egg yolks and peanuts, and in the human body. It is also used as a medicine.

Palmitoylethanolamide is used for pain, neuropathic pain, fibromyalgia, multiple sclerosis (MS), carpal tunnel syndrome, infections of the airway, and many other conditions, but there is no good scientific evidence to support these uses.

Palmitoylethanolamide is a chemical that can bind to cells in the body and reduce pain and swelling.

When taken by mouth: Taking palmitoylethanolamide is POSSIBLY SAFE for most adults when used for up to 3 months. Possible side effects, such as upset stomach, are very rare. There isn't enough reliable information to know if palmitoylethanolamide is safe to use for longer than 3 months.

When applied to the skin: There isn't enough reliable information to know if palmitoylethanolamide is safe to use or what the side effects might be.

Special Precautions & Warnings:

Pregnancy and breast-feeding: There isn't enough reliable information to know if palmitoylethanolamide is safe to use when pregnant or breast feeding. Stay on the safe side and avoid use.

Infants and children:Taking palmitoylethanolamide by mouth up to 10 weeks is POSSIBLY SAFE for children aged 4-12 years.

There are no known interactions with medications. Before taking this product, talk with your health professional if you take any medications.

There are no known interactions with herbs and supplements.

There are no known interactions with foods.

The following doses have been studied in scientific research:



  • Pain: Palmitoylethanolamide 300-1,200 mg daily for up to 60 days.

Hydroxyethylpalmitamide, Impulsin, N-(2-Hydroxyethyl) hexadecanamide, N-(2-Hydroxyethyl)palmitamide, Palmidrol, Palmitamide MEA, Palmitic Acid Monoethanolamide, Palmitoylethanolamine, PEA.

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