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Resveratrol is a chemical mostly found in red grapes and products made from these grapes (wine, juice). It may be helpful for hay fever and weight loss.
Resveratrol might have many effects in the body, including expanding blood vessels and reducing blood clotting. It may also decrease pain and swelling, reduce levels of sugar in the blood, and help the body fight against disease.
Resveratrol is most commonly used for high cholesterol, cancer, heart disease, and many other conditions. But there is no strong evidence to support resveratrol for any use.
- Allergic rhinitis (hay fever). Intranasal resveratrol seems to be beneficial for reducing allergic rhinitis symptoms in adults and children.
Login for details - Obesity. Oral resveratrol seems to be beneficial for weight loss in overweight or obese individuals. However, it is unlikely to be beneficial for improving most metabolic parameters in this population.
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- Cardiovascular disease (CVD). Oral resveratrol does not seem to be beneficial for CVD prevention.
Login for details - Hypercholesterolemia. Oral resveratrol does not seem to be beneficial for hypercholesterolemia.
Login for details - Metabolic syndrome. Oral resveratrol does not seem to be beneficial for metabolic syndrome.
Login for details - Nonalcoholic fatty liver disease (NAFLD). Oral resveratrol does not seem to be beneficial for most metabolic symptoms of NAFLD. It is unclear if oral resveratrol is beneficial for improving steatosis.
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- Acne. It is unclear if topical resveratrol is beneficial for acne.
Login for details - Age-related cognitive decline. It is unclear if oral resveratrol is beneficial for age-related cognitive decline.
Login for details - Aging skin. Login for details
- Alzheimer disease. It is unclear if oral resveratrol is beneficial for Alzheimer disease.
Login for details - Beta-thalassemia. It is unclear if oral resveratrol is beneficial for beta-thalassemia.
Login for details - Cancer. It is unclear if dietary resveratrol is beneficial for cancer prevention.
Login for details - Chronic obstructive pulmonary disease (COPD). Oral resveratrol has only been evaluated in combination with other ingredients; its effect when used alone is unclear.
Login for details - Cognitive function. Oral resveratrol has only been evaluated in combination with other ingredients; its effect when used alone is unclear.
Login for details - Cognitive impairment. Oral resveratrol has only been evaluated in combination with other ingredients; its effect when used alone is unclear.
Login for details - Coronavirus disease 2019 (COVID-19). It is unclear if oral resveratrol is beneficial for COVID-19.
Login for details - Diabetes. Some research shows that oral resveratrol is beneficial for improving glycemic indices in patients with type 2 diabetes. However, more research is needed to determine the most effective dose or the patient population most likely to benefit.
Login for details - Diabetic nephropathy. It is unclear if oral resveratrol is beneficial for diabetic nephropathy.
Login for details - Hypertension. It is unclear if oral resveratrol is beneficial for lowering blood pressure.
Login for details - Migraine headache. It is unclear if oral resveratrol is beneficial for treating migraine headache.
Login for details - Mitochondrial myopathies. It is unclear if oral resveratrol is beneficial for increasing exercise tolerance in patients with mitochondrial myopathies.
Login for details - Osteoarthritis. It is unclear if oral resveratrol is beneficial for osteoarthritis.
Login for details - Osteopenia. It is unclear if oral resveratrol is beneficial for improving bone mineral density (BMD).
Login for details - Peritoneal dialysis. It is unclear if oral resveratrol can improve outcomes with peritoneal dialysis.
Login for details - Polycystic ovary syndrome (PCOS). It is unclear if oral resveratrol is beneficial for PCOS.
Login for details - Rheumatoid arthritis (RA). It is unclear if oral resveratrol is beneficial for RA.
Login for details - Ulcerative colitis. It is unclear if oral resveratrol is beneficial for ulcerative colitis.
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When taken by mouth: People often consume resveratrol in small amounts in foods. Resveratrol supplements are possibly safe when taken by mouth in doses up to 1500 mg daily for up to 3 months. Higher doses of up to 2000-3000 mg daily have been used safely for 2-6 months. But these higher doses are more likely to cause stomach upset.
When applied to the skin: Resveratrol is possibly safe when used for up to 30 days.
When sprayed into the nose: Resveratrol is possibly safe when used for up to 4 weeks.
Special Precautions & Warnings:
Pregnancy and breast-feeding: Resveratrol is likely safe when used in amounts found in some foods. However, during pregnancy and breast-feeding, the source of resveratrol is important. Resveratrol is found in grape skins, grape juice, wine, and other food sources. Wine should not be used as a source of resveratrol when pregnant or breast-feeding.Children: People often consume resveratrol in small amounts in foods. But there isn't enough reliable information to know if it safe to take by mouth in larger amounts. Resveratrol is possibly safe in children when sprayed in the nose for up to 2 months.
Bleeding disorders: Resveratrol might slow blood clotting and increase the risk of bleeding in people with bleeding disorders.
Hormone-sensitive condition such as breast cancer, uterine cancer, ovarian cancer, endometriosis, or uterine fibroids: Resveratrol might act like estrogen. If you have any condition that might be made worse by exposure to estrogen, don't use resveratrol.
Surgery: Resveratrol might increase the risk of bleeding during and after surgery. Stop using resveratrol at least 2 weeks before a scheduled surgery.
Medications changed by the liver (Cytochrome P450 1A2 (CYP1A2) substrates)
Interaction Rating=Moderate Be cautious with this combination.
Some medications are changed and broken down by the liver. Resveratrol might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.
Medications changed by the liver (Cytochrome P450 2C19 (CYP2C19) substrates)
Interaction Rating=Moderate Be cautious with this combination.
Some medications are changed and broken down by the liver. Resveratrol might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.
Medications changed by the liver (Cytochrome P450 2E1 (CYP2E1) substrates)
Interaction Rating=Moderate Be cautious with this combination.
Some medications are changed and broken down by the liver. Resveratrol might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.
Medications changed by the liver (Cytochrome P450 3A4 (CYP3A4) substrates)
Interaction Rating=Moderate Be cautious with this combination.
Some medications are changed and broken down by the liver. Resveratrol might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.
Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs)
Interaction Rating=Moderate Be cautious with this combination.
Resveratrol might slow blood clotting. Taking resveratrol along with medications that also slow blood clotting might increase the risk of bruising and bleeding.
Herbs and supplements that might slow blood clotting: Resveratrol might slow blood clotting and increase the risk of bleeding. Taking it with other supplements with similar effects might increase the risk of bleeding in some people. Examples of supplements with this effect include garlic, ginger, ginkgo, nattokinase, and Panax ginseng.
Resveratrol can be taken with or without food. But taking resveratrol with fatty foods might reduce how much the body absorbs.
Resveratrol has most often been used by adults in doses of 250-1000 mg by mouth daily for up to 3 months. It is also sometimes used in nasal sprays. Speak with a healthcare provider to find out what dose might be best for a specific condition.
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