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Riboflavin is vitamin B2. It is widely found in both plant- and animal-based foods, including milk, meat, eggs, nuts, enriched flour, and green vegetables.

Riboflavin is involved in many body processes. It's required for the proper development of the skin, lining of the digestive tract, blood cells, and brain function.

People most commonly use riboflavin to prevent riboflavin deficiency, for migraine, and for high levels of homocysteine in the blood. It's also used for acne, muscle cramps, and many other conditions, but there is no good scientific evidence to support these other uses.

Natural Medicines rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, Ineffective, and Insufficient Evidence to Rate.
No data available.
  • Hyperhomocysteinemia.  Oral riboflavin reduces homocysteine levels in individuals with the MTHFR 677 TT genotype. It does not seem to provide benefit in individuals with other genotypes.
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  • Migraine headache.  Oral riboflavin modestly reduces migraine attack frequency and severity in adults. The benefits of oral riboflavin in children are unclear.
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No data available.
No data available.
No data available.
No data available.

When taken by mouth: Riboflavin is likely safe for most people in doses of up to 400 mg daily. In some people, riboflavin can cause the urine to turn a bright yellow color. It may also cause nausea.

Special Precautions & Warnings:

Pregnancy and breast-feeding: Riboflavin is likely safe when consumed in amounts commonly found in foods. The recommended intake is 1.4 mg daily during pregnancy and 1.6 mg daily during lactation.

Children: Riboflavin is likely safe for most children when consumed in amounts commonly found in foods. Higher doses of 100-200 mg daily have also been safely used.

Liver disease: Riboflavin absorption is decreased in people with liver disease.

Drying medications (Anticholinergic drugs)

Interaction Rating=Minor Be watchful with this combination.

Some drying medications can affect the stomach and intestines. Taking these drying medications with riboflavin (vitamin B2) can increase the amount of riboflavin that is absorbed in the body. But it's not known if this interaction is important.

Medications for depression (Tricyclic antidepressants)

Interaction Rating=Minor Be watchful with this combination.

Some medications for depression can decrease the amount of riboflavin in the body. This interaction is not a big concern because it only occurs with very large amounts of some medications for depression.

Phenobarbital (Luminal)

Interaction Rating=Minor Be watchful with this combination.

Riboflavin is broken down by the body. Phenobarbital might increase how quickly riboflavin is broken down in the body. It is not clear if this interaction is significant.

Probenecid (Benemid)

Interaction Rating=Minor Be watchful with this combination.

Probenecid (Benemid) can increase how much riboflavin is in the body. This might cause there to be too much riboflavin in the body. But it's not known if this interaction is a big concern.

Blond psyllium: Psyllium reduces absorption of riboflavin from supplements in healthy individuals. It isn't clear whether it reduces absorption of riboflavin found in foods, or whether this interaction can impact health.
Boron: A form of boron, called boric acid, might reduce the absorption of riboflavin.
Iron: In people with riboflavin and iron deficiency, riboflavin supplements may improve the effects of iron supplements.

There are no known interactions with foods.

Riboflavin is an important nutrient that is found in many foods. The amount that should be consumed on a daily basis is called the recommended dietary allowance (RDA). For adult males, the RDA is 1.3 mg daily. For adult females, the RDA is 1.1 mg daily. During pregnancy, the RDA is 1.4 mg, and during breastfeeding, the RDA is 1.6 mg. Recommended amounts for children depend on age.

Riboflavin is also available in supplements. Taking riboflavin supplements with food will increase how much the body absorbs. Speak with a healthcare provider to find out what dose might be best for a specific condition.

B Complex Vitamin, Complexe de Vitamines B, Flavin, Flavine, Lactoflavin, Lactoflavine, Riboflavin 5' Phosphate, Riboflavin Tetrabutyrate, Riboflavina, Riboflavine, Vitamin B2, Vitamin G, Vitamina B2, Vitamine B2, Vitamine G.

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