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Ribose is a kind of sugar that is produced by the body. It is used as a medicine.

Ribose is used for heart disease, mental function, athletic performance, chronic fatigue syndrome (CFS), fibromyalgia, and many other conditions, but there is no good scientific evidence to support these uses.

Ribose is an energy source that the body makes from food. There is some evidence that supplemental ribose might prevent muscle fatigue in people with genetic disorders that prevent sufficient energy production by the body. It might provide extra energy to the heart during exercise in people with heart disease.

When taken by mouth: Ribose is LIKELY SAFE when consumed in food amounts. It is also LIKELY SAFE for most people when taken for up to 1 month as medicine. It can cause some side effects including diarrhea, stomach discomfort, nausea, headache, and low blood sugar. There isn't enough reliable information to know if ribose is safe to use for longer than 3 weeks.

When given by IV: Ribose is LIKELY SAFE when administered by a healthcare provider.

Special Precautions & Warnings:

Pregnancy and breast-feeding: There isn't enough reliable information to know if ribose is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.

Diabetes: Ribose might lower blood sugar. When used along with diabetes medications that lower blood sugar, it might make blood sugar drop too low. It's best not to use ribose if you have diabetes.

Surgery: Since ribose might lower blood sugar, there is a concern that it might interfere with blood sugar control during and after surgery. Stop taking ribose at least 2 weeks before a scheduled surgery.

Alcohol

Interaction Rating=Minor Be watchful with this combination.

Alcohol might decrease your blood sugar. Ribose might also decrease your blood sugar. Taking ribose along with alcohol might cause your blood sugar to go too low.

Aspirin

Interaction Rating=Minor Be watchful with this combination.

Ribose might decrease blood sugar. Large amounts of aspirin might also decrease blood sugar. Taking ribose along with large amounts of aspirin might cause your blood sugar to go too low. But this interaction probably isn't a big concern for most people that take 81 mg of aspirin a day.

Choline Magnesium Trisalicylate (Trilisate)

Interaction Rating=Minor Be watchful with this combination.

Choline magnesium trisalicylate (Trilisate) might decrease your blood sugar. Ribose might also decrease blood sugar. Taking ribose along with choline magnesium trisalicylate (Trilisate) might cause your blood sugar to be too low. But it is not clear if this interaction is a big concern.

Insulin

Interaction Rating=Moderate Be cautious with this combination.

Ribose might decrease blood sugar. Insulin is also used to decrease blood sugar. Taking ribose along with insulin might cause your blood sugar to be too low. Monitor your blood sugar closely. The dose of your insulin might need to be changed.

Medications for diabetes (Antidiabetes drugs)

Interaction Rating=Moderate Be cautious with this combination.

Ribose might decrease blood sugar. Diabetes medications are also used to lower blood sugar. Taking ribose along with diabetes medications might cause your blood sugar to go too low. Monitor your blood sugar closely. The dose of your diabetes medication might need to be changed.

Some medications used for diabetes include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, pioglitazone (Actos), rosiglitazone (Avandia), chlorpropamide (Diabinese), glipizide (Glucotrol), tolbutamide (Orinase), and others.

Propranolol (Inderal)

Interaction Rating=Minor Be watchful with this combination.

Propanolol (Inderal) might decrease blood sugar. Ribose might also decrease blood sugar. Taking ribose along with propanolol (Inderal) might cause your blood sugar to go too low.

Salsalate (Disalcid)

Interaction Rating=Minor Be watchful with this combination.

Large amounts of salsalate (Disalcid) can cause blood sugar to become low. Taking salsalate along with ribose might cause blood sugar to become too low.

Herbs and supplements that might lower blood sugar: Ribose might lower blood sugar levels. Taking it along with other herbs and supplements that might lower blood sugar might cause blood sugar to drop too low. Some herbs and supplements that might lower blood sugar include alpha-lipoic acid, bitter melon, chromium, devil's claw, fenugreek, garlic, guar gum, horse chestnut, Panax ginseng, psyllium, Siberian ginseng, and others.

There are no known interactions with foods.

The appropriate dose of ribose depends on several factors such as the user's age, health, and several other conditions. At this time, there is not enough scientific information to determine an appropriate range of doses for ribose. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

Beta-D-ribofuranose, D-ribosa, D-ribose, Ribosa.

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