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Saccharomyces boulardii is a yeast believed to be a strain of Saccharomyces cerevisiae. It is likely effective for treating certain types of diarrhea.

Saccharomyces boulardii is called a "probiotic," a friendly organism that helps to fight off "bad" organisms that might cause diseases. Saccharomyces boulardii is different from other strains of Saccharomyces cerevisiae, commonly known as brewer's yeast and baker's yeast.

Saccharomyces boulardii is most commonly used for treating and preventing diarrhea, including rotaviral diarrhea in children. It has some evidence of use for other types of diarrhea, acne, and a digestive tract infection that can lead to ulcers. There is no good evidence to support using Saccharomyces boulardii for COVID-19.

Natural Medicines rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, Ineffective, and Insufficient Evidence to Rate.
No data available.
  • Diarrhea.  In children, oral Saccharomyces boulardii reduces the duration of acute diarrhea and the duration of hospitalization for acute diarrhea. It is unclear if it is beneficial in adults.
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  • Sepsis.  In preterm infants, oral Saccharomyces boulardii does not seem to be beneficial for sepsis prevention.
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No data available.
No data available.
No data available.

When taken by mouth: Saccharomyces boulardii is likely safe for most adults when used for up to 15 months. It can cause gas in some people.

Special Precautions & Warnings:

Pregnancy and breast-feeding: There isn't enough reliable information to know if Saccharomyces boulardii is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.

Children: Saccharomyces boulardii is possibly safe for children when taken by mouth appropriately. However, diarrhea in children should be evaluated by a healthcare professional before using Saccharomyces boulardii.

Elderly: The elderly might have an increased risk of fungal infection when taking Saccharomyces boulardii. Stay on the safe side and avoid use.

Weakened immune system: Saccharomyces boulardii has caused fungal infections in people with weakened immune systems. This includes people with HIV/AIDS or cancer, or people who are taking medications to prevent rejection of a transplanted organ. In many cases, fungemia resulted from catheter contamination by air, environmental surfaces, or hands that have been contaminated with Saccharomyces boulardii. If you have a weakened immune system, talk with your healthcare provider before taking Saccharomyces boulardii.

Yeast allergy: People with yeast allergy can be allergic to products containing Saccharomyces boulardii. Stay on the safe side and avoid these products.

Medications for fungal infections (Antifungals)

Interaction Rating=Minor Be watchful with this combination.

Saccharomyces boulardii is a fungus. Medications for fungal infections help reduce fungus in and on the body. Taking Saccharomyces boulardii with medications for fungal infections can reduce the effectiveness of Saccaromyces boulardii.

Some medications for fungal infection include fluconazole (Diflucan), terbinafine (Lamisil), itraconazole (Sporanox), and others.

There are no known interactions with herbs and supplements.

There are no known interactions with foods.

In adults, Saccharomyces boulardii has most often been taken by mouth in doses of 500-1000 mg (about 10-20 billion colony-forming units) daily for 4 weeks. In children, Saccharomyces boulardii has most often been taken by mouth in doses of 250-500 mg (about 5-10 billion colony-forming units) for up to 4 weeks.

Probiotic, Probiotique, Saccharomyces, Saccharomyces Boulardii CNCM I-745, Saccharomyces Boulardii HANSEN CBS 5926, Saccharomyces Boulardii Lyo CNCM I-745, Saccharomyces Boulardius, Saccharomyces Cerevisiae Boulardii, Saccharomyces Cerevisiae (Boulardii), Saccharomyces Cerevisiae (Boulardii) HANSEN CBS 5926, Saccharomyces Cerevisiae HANSEN CBS 5926, Saccharomyces cerevisiae var boulardii, S. Boulardii, SCB.

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