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Safflower (Carthamus tinctorius) is a plant that grows throughout the world. Its seed oil is a rich source of the essential fatty acid, linoleic acid.
The linoleic acid in safflower oil might help reduce the risk of heart disease. Safflower also contains chemicals that might help prevent blood clots, widen blood vessels, lower blood pressure, and stimulate the heart.
People use safflower oil for high cholesterol, heart disease, stroke, diabetes, and many other conditions, but there is no good scientific evidence to support most of these uses.
- Hypercholesterolemia. Several small studies suggest that oral safflower oil, as a substitute for coconut oil, butter, or other animal fats in the diet, may reduce total and low-density lipoprotein (LDL) cholesterol levels in patients with or without hypercholesterolemia.
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- Coronary heart disease (CHD). Safflower oil, which is high in oleic acid, may be beneficial for reducing the risk of CHD when used to replace other dietary oils.
Login for details - Cystic fibrosis. It is unclear if oral safflower oil is beneficial in children with cystic fibrosis.
Login for details - Diabetes. Small clinical studies of oral safflower oil for improving glycemic control in patients with diabetes have yielded mixed results.
Login for details - Diabetic nephropathy. Small clinical studies suggest that intravenous safflower yellow, a component of safflower flower, might improve symptoms and markers of diabetic nephropathy.
Login for details - Familial hypercholesterolemia. Small clinical studies suggest that substituting safflower oil in place of butter in the diet may modestly reduce cholesterol levels in patients with familial hypercholesterolemia.
Login for details - Hepatitis C. Oral safflower oil has only been evaluated in combination with other ingredients; its effect when used alone is unclear.
Login for details - Hypertension. It is unclear if oral safflower oil is beneficial for reducing blood pressure; the available research is conflicting.
Login for details - Low birth weight. It is unclear if oral safflower oil is beneficial in infants with low birth weight.
Login for details - Metabolic syndrome. It is unclear if oral safflower oil is beneficial in patients with metabolic syndrome.
Login for details - Obesity. Login for details
- Myocardial infarction. Intravenous safflower yellow, a component of safflower flower, might improve outcomes when used as an adjunct to conventional therapy for the treatment of acute coronary syndrome (ACS).
Login for details - Phrynoderma. It is unclear if oral safflower oil is beneficial in patients with phrynoderma.
Login for details - Scarring. Topical safflower oil has only been evaluated in combination with other ingredients; its effect when used alone is unclear.
Login for details - Stroke. Small clinical studies suggest that intravenous safflower yellow, a constituent of safflower flower, as an adjunct to conventional treatments, may improve neurological outcomes post-stroke.
Login for details - Unstable angina. Intravenous safflower yellow, a component of safflower flower, might improve outcomes when used as an adjunct to conventional therapy for the treatment of unstable angina.
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When taken by mouth: Safflower oil is likely safe to use as part of the diet. It's usually well-tolerated.
When applied to the skin: Safflower oil is possibly safe when used for up to 8 weeks.
Special Precautions & Warnings:
Pregnancy: Safflower oil is likely safe to use as part of the diet. Safflower flower is likely unsafe when used during pregnancy. It has effects that may lead to a miscarriage.Breast-feeding: Safflower oil is likely safe to use as part of the diet. There isn't enough reliable information to know if safflower flower is safe to use when breast-feeding. Stay on the safe side and avoid use.
Children: Safflower oil is possibly safe when taken by mouth in children for up to 8 weeks. There isn't enough reliable information to know if safflower flower is safe for children.
Bleeding problems (hemorrhagic diseases, stomach or intestinal ulcers, or clotting disorders): Safflower can slow blood clotting and might increase the risk of bleeding in people with bleeding disorders.
Allergy to ragweed and related plants: Safflower may cause an allergic reaction in people who are sensitive to the Asteraceae/Compositae family. Members of this family include ragweed, chrysanthemums, marigolds, daisies, and many others.
Diabetes: Safflower oil might increase blood sugar. This might make it harder to control blood sugar levels in people with diabetes.
Surgery: Safflower oil might slow blood clotting. This might increase the risk of bleeding during and after surgery. Stop using safflower oil at least 2 weeks before a scheduled surgery.
Medications for diabetes (Antidiabetes drugs)
Interaction Rating=Moderate Be cautious with this combination.
Safflower oil might increase blood sugar levels. Taking safflower oil along with diabetes medications might reduce the effects of these medications. Monitor your blood sugar closely.
Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs)
Interaction Rating=Moderate Be cautious with this combination.
Safflower oil might slow blood clotting. Taking safflower oil along with medications that also slow blood clotting might increase the risk of bruising and bleeding.
Warfarin
Interaction Rating=Moderate Be cautious with this combination.
Warfarin is used to slow blood clotting. Safflower oil might increase the effects of warfarin. Increasing the effects of warfarin might increase the risk of bruising and bleeding. Be sure to have your blood checked regularly. The dose of your warfarin might need to be changed.
Herbs and supplements that might lower blood sugar: Safflower oil might increase blood sugar. Taking it with supplements that lower blood sugar might reduce the effects of these products. Examples of supplements that lower blood sugar include aloe, bitter melon, cassia cinnamon, chromium, and prickly pear cactus.
Herbs and supplements that might slow blood clotting: Safflower oil might slow blood clotting and increase the risk of bleeding. Taking it with other supplements with similar effects might increase the risk of bleeding in some people. Examples of supplements with this effect include garlic, ginger, ginkgo, nattokinase, and Panax ginseng.
There are no known interactions with foods.
Safflower oil has most often been used by adults in doses of 20-30 mL by mouth daily for up to 8 weeks. Speak with a healthcare provider to find out what dose might be best for a specific condition.
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