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Tianeptine is a prescription drug for depression in some European, Asian, and Latin American countries. Tianeptine is not approved as a prescription drug or dietary supplement in the U.S.

Tianeptine is most commonly used for depression. It is also used for pain, asthma, anxiety, and other conditions, but there is no good scientific evidence to support these uses. Tianeptine might also be unsafe. Tianeptine has been associated with dependence, withdrawal, and serious adverse events including death.

Natural Medicines rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, Ineffective, and Insufficient Evidence to Rate.

Tianeptine is chemical that affects brain chemicals. It seems to affect mood when used in low doses. In higher doses, it works like an opioid and can cause addiction and other serious side effects. It can also cause withdrawal.

When taken by mouth: Tianeptine is POSSIBLY UNSAFE when taken by mouth. While tianeptine is available by prescription in certain countries, it has a risk of misuse and abuse. Taking high doses of tianeptine can cause drowsiness, confusion, difficulty breathing, coma, and death. Use of tianeptine over a long time can cause withdrawal.

When given by IV: Tianeptine is LIKELY UNSAFE when given by IV. Tianeptine can cause drowsiness, confusion, difficulty breathing, coma, and death. Use of tianeptine over a long time can cause withdrawal. Tianeptine is not approve for IV use in the U.S. or elsewhere.

Special Precautions & Warnings:

Pregnancy: Tianeptine is POSSIBLY UNSAFE when taken by mouth during pregnancy. It can cause the infants to be born addicted to tianeptine. Infants present with symptoms of crying, sweating, poor feeding, and vomiting.

Breast-feeding: There is not enough reliable information about the safety of taking tianeptine if you are breast-feeding. But other drugs that are similar to tianeptine are known to enter the breastmilk when used by the mother. Stay on the safe side and avoid use.

History of drug abuse: Using tianeptine for a long time can cause dependence and withdrawal, especially in people that have been addicted to other chemicals. Do not take tianeptine if you have had an addiction.

Surgery: Tianeptine may have sedative effects in higher doses. Healthcare providers worry that anesthesia and other medications during and after surgery might increase this effect. Stop taking tianeptine at least 2 weeks before a scheduled surgery.

There are no known interactions with medications. Before taking this product, talk with your health professional if you take any medications.

Herbs and supplements with sedative properties: Tianeptine might cause sleepiness and drowsiness. Using tianeptine along with other herbs and supplements that can cause sleepiness and drowsiness might cause too much of this effect. Some of these supplements include 5-HTP, calamus, California poppy, catnip, hops, Jamaican dogwood, kava, St. John's wort, valerian, yerba mansa, and others.

There are no known interactions with foods.

The following doses have been studied in scientific research:


  • Depression: 25 or 37.5 mg of tianeptine daily has been used as a prescription drug under the guidance of a healthcare professional. Tianeptine is not available as a prescription drug in the U.S.

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