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Vitamin E is an essential nutrient that contains tocotrienols and tocopherols. Both tocotrienols and tocopherols have similar chemical structures. The difference between tocotrienols and tocopherols is that tocotrienols have double bonds. Tocotrienols are often found in natural sources such as annatto, palm, or rice brain oil.

People use tocotrienols for high cholesterol, scars, cancer, an inherited disorder called familial dysautonomia, a build-up of fat in the liver in people who drink little or no alcohol (nonalcoholic fatty liver disease or NAFLD), and many other conditions, but there is no good scientific evidence to support these uses.

Natural Medicines rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, Ineffective, and Insufficient Evidence to Rate.
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Tocotrienols exist in four different forms: alpha-, beta-, gamma-, and delta-tocotrienols. Tocotrienols seem to have many different effects in the body. Tocotrienols might lower cholesterol levels and provide heart health benefits. Tocotrienols also seem to benefit people with a genetic disorder called familial dysautonomia by increasing levels of a certain protein in blood cells.

When taken by mouth: Tocotrienols are POSSIBLY SAFE when taken by mouth. Tocotrienols have been used safely in clinical trials at doses of up to 600 mg daily for 6 months. Tocotrienols have also been used safely at a dose of 200 mg daily for up to 5 years.

When applied to the skin: There isn't enough reliable information to know if tocotrienols are safe when applied to the skin. In some people, tocotrienol cream can cause mild itching.

Special Precautions & Warnings:

Pregnancy and breast-feeding: There isn't enough reliable information to know if it is safe to use tocotrienols when pregnant or breast-feeding. Stay on the safe side and avoid use.

There are no known interactions with medications. Before taking this product, talk with your health professional if you take any medications.

There are no known interactions with herbs and supplements.

There are no known interactions with foods.

The appropriate dose of tocotrienols depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for tocotrienols (in children/in adults). Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

(2R)-2,5,7,8-tetramethyl-2-[(3E,7E)-4,8,12-trimethyltrideca-3,7,11-trienyl]-3,4-dihydrochromen-6-ol; (2R)-2,5,8-trimethyl-2-[(3E,7E)-4,8,12-trimethyltrideca-3,7,11-trienyl]-3,4-dihydrochromen-6-ol; (2R)-2,7,8-trimethyl-2-[(3E,7E)-4,8,12-trimethyltrideca-3,7,11-trienyl]-3,4-dihydrochromen-6-ol; (2R)-2,8-dimethyl-2-[(3E,7E)-4,8,12-trimethyltrideca-3,7,11-trienyl]-3,4-dihydrochromen-6-ol, 8-Methyltocotrienol, Alpha-Tocotrienol, Beta-Tocotrienol, Delta-Tocotrienol, Epsilon-Tocopherol, Epsilon-Tokoferol, Gamma-Tocotrienol, Zeta1-Tocopherol.

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