Tyrosine is an amino acid. Amino acids are the building blocks of protein. The body makes tyrosine from another amino acid called phenylalanine. Tyrosine can also be found in dairy products, meats, fish, eggs, nuts, beans, oats, and wheat.
Tyrosine is most commonly used in protein supplements for an inherited disorder called phenylketonuria (PKU). It is also used for alcoholism, cocaine dependence, and memory and thinking skills, but there is no good scientific evidence to support these uses.
- Phenylketonuria (PKU).  Oral tyrosine as a component of medical foods is recommended in people with PKU, a disorder in which phenylalanine cannot be endogenously metabolized into tyrosine.
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- Cognitive function.  Taking tyrosine orally might improve cognitive function in patients exposed to stressors such as cold or noise.
Login for details - Memory.  Taking tyrosine orally seems to improve memory in patients exposed to stressors such as cold or those having to complete multiple tasks at once.
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- Athletic performance.  Oral tyrosine does not improve athletic performance when taken prior to exercise.
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- Alcoholism.  Oral tyrosine has only been evaluated in combination with other ingredients; its effect when used alone is unclear.
Login for details - Attention deficit-hyperactivity disorder (ADHD).  It is unclear if oral tyrosine is beneficial for improving ADHD symptoms.
Login for details - Cocaine dependence.  Oral tyrosine has only been evaluated in combination with other ingredients; its effect when used alone is unclear.
Login for details - Dementia.  Oral tyrosine has only been evaluated in combination with other ingredients; its effect when used alone is unclear.
Login for details - Depression.  It is unclear if oral tyrosine is beneficial for improving major depressive disorder.
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- Hypertension.  It is unclear if oral tyrosine is beneficial for reducing hypertension of mild severity.
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- Narcolepsy.  It is unclear if oral tyrosine is beneficial for improving narcolepsy symptoms.
Login for details - Obesity.  Oral tyrosine has only been evaluated for in combination with other ingredients; its effect when used alone is unclear.
Login for details - Opioid withdrawal.  Oral tyrosine has only been evaluated for heroin withdrawal in combination with other ingredients; its effect when used alone is unclear.
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- Premenstrual syndrome (PMS). Login for details
- Schizophrenia.  It is unclear if oral tyrosine is beneficial for improving schizophrenia symptoms.
Login for details - Sleep deprivation.  It is unclear if oral tyrosine is beneficial for improving alertness in sleep deprived adults.
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- Wrinkled skin.  Topical tyrosine has only been evaluated in combination with other ingredients; its effect when used alone is unclear.
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The body uses tyrosine, an amino acid, to make chemical messengers that are involved in conditions involving the brain such as mental alertness.
When taken by mouth: Tyrosine is LIKELY SAFE when taken in food amounts. It is POSSIBLY SAFE when taken by adults as a medicine, short-term. Tyrosine seems to be safe when taken in doses up to 150 mg/kg daily for up to 3 months. Some people experience side effects such as nausea, headache, fatigue, and heartburn.
When applied to the skin: Tyrosine is POSSIBLY SAFE when applied to the skin.
Special Precautions & Warnings:
Pregnancy and breast-feeding: There isn't enough reliable information to know if tyrosine is safe to use when pregnant or breast-feeding. Stay on the safe side and stick to food amounts.Thyroid disorders: The body uses tyrosine to make thyroxine, a thyroid hormone. Taking extra tyrosine might increase thyroxine levels too much. This could make hyperthyroidism and Graves disease worse. If you have a thyroid disorder, don't take tyrosine supplements.
Levodopa
Interaction Rating=Moderate Be cautious with this combination.
Tyrosine might decrease how much levodopa the body absorbs. By decreasing how much levodopa the body absorbs, tyrosine might decrease the effectiveness of levodopa. Do not take tyrosine and levodopa at the same time.
Thyroid hormone
Interaction Rating=Moderate Be cautious with this combination.
The body naturally produces thyroid hormones. Tyrosine might increase how much thyroid hormone the body produces. Taking tyrosine with thyroid hormone pills might cause there to be too much thyroid hormone. This could increase the effects and side effects of thyroid hormones.
There are no known interactions with herbs and supplements.
There are no known interactions with foods.
The following doses have been studied in scientific research:
ADULTS
BY MOUTH:
- For memory and thinking skills (cognitive function): A single dose of 100-300 mg/kg or 2 grams of tyrosine has been taken before a stressful mental task.
- For memory: 150-300 mg/kg of tyrosine has been used before a memory task.
- For an inherited disorder that increases levels of phenylalanine in the blood (phenylketonuria or PKU): Foods and medical foods providing 4-6 grams of tyrosine daily are recommended. Women with PKU who are pregnant or breastfeeding are advised to consume foods providing 6-7.6 grams of tyrosine daily. A doctor will measure tyrosine levels in the blood to make sure they don't become too high or too low. For most people with PKU, additional separate supplementation with free tyrosine is not recommended. It can cause wide variations in the amount of tyrosine in the blood. This could cause unwanted side effects.
BY MOUTH:
- For an inherited disorder that increases levels of phenylalanine in the blood (phenylketonuria or PKU): Foods and medical foods providing tyrosine 1.1-6.0 grams daily, depending on age, are recommended from infancy. A doctor will measure tyrosine levels in the blood to make sure they don't become too high or too low. For most people with PKU, additional separate supplementation with free tyrosine is not recommended. It can cause wide variations in the amount of tyrosine in the blood. This could cause unwanted side effects.
2-Acetylamino-3-(4-Hydroxyphenyl)-Propanoic Acid, Acetyl-L-Tyrosine, Acétyl-L-Tyrosine, L-Tyrosine, N-Acetyl L-Tyrosine, N-Acetyl-L-Tyrosine, N-Acétyl L-Tyrosine, N-Acetyl-Tyrosine, N-Acétyl-Tyrosine, Tirosina, Tyr, Tyrosinum, 2-amino-3-(4-hydroxyphenyl)propionic acid.
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