+ Add to myCart

Vitamin B6 is a type of B vitamin. Pyridoxine, pyridoxal, and pyridoxamine are all forms of vitamin B6. It's found in certain foods and also made in a lab.

Vitamin B6 is needed for the proper function of sugars, fats, and proteins in the body. It's also necessary for the development of the brain, nerves, skin, and many other parts of the body. It's found in cereals, legumes, and eggs, and often used with other B vitamins in vitamin B complex products.

People commonly use vitamin B6 for preventing and treating vitamin B6 deficiency. It is also used for heart disease, premenstrual syndrome (PMS), depression, morning sickness, Alzheimer disease, menstrual cramps, diabetes, and many other conditions, but there is no good scientific evidence to support many of these other uses.

Natural Medicines rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, Ineffective, and Insufficient Evidence to Rate.
No data available.
No data available.
No data available.

When taken by mouth: Vitamin B6 is likely safe when used appropriately. Taking vitamin B6 in doses of 100 mg daily or less is generally considered to be safe. Vitamin B6 is possibly safe when taken in doses of 101-200 mg daily. In some people, vitamin B6 might cause nausea, stomach pain, loss of appetite, headache, and other side effects. Vitamin B6 is possibly unsafe when taken in doses of 500 mg or more daily. High doses of vitamin B6, especially 1000 mg or more daily, might cause brain and nerve problems.

Special Precautions & Warnings:

Pregnancy: Vitamin B6 is likely safe when taken by mouth, appropriately. It's sometimes used to control morning sickness, but should only be done so under the supervision of a healthcare provider. Taking high doses is possibly unsafe. High doses might cause newborns to have seizures.

Breast-feeding: Vitamin B6 is likely safe when taken in doses of 2 mg by mouth daily. Avoid using higher amounts. There isn't enough reliable information to know if taking higher doses of vitamin B6 is safe when breast-feeding.

Post-surgical stent placement. Avoid using a combination of vitamin B6, folate, and vitamin B12 after receiving a coronary stent. This combination may increase the risk of blood vessel narrowing.

Weight loss surgery. Taking a vitamin B6 supplement is not needed for people that have had weight loss surgery. Taking too much might increase the chance of side effects such as nausea, vomiting, and browning skin.

Amiodarone (Cordarone)

Interaction Rating=Moderate Be cautious with this combination.

Amiodarone (Cordarone) might increase your sensitivity to sunlight. Taking vitamin B6 (pyridoxine) along with amiodarone (Cordarone) might increase the chances of sunburn, blistering, or rashes on areas of skin exposed to sunlight. Be sure to wear sunblock and protective clothing when spending time in the sun.


Interaction Rating=Minor Be watchful with this combination.

The body breaks down levodopa to get rid of it. Vitamin B6 (pyridoxine) can increase how quickly the body breaks down and gets rid of levodopa. But this is only a problem if you are taking levodopa alone. Most people take levodopa along with carbidopa (Sinemet). Carbidopa prevents this interaction from occurring. If you are taking levodopa without carbidopa do not take vitamin B6.

Phenobarbital (Luminal)

Interaction Rating=Moderate Be cautious with this combination.

The body breaks down phenobarbital (Luminal) to get rid of it. Pyridoxine might increase how quickly the body breaks down phenobarbital (Luminal). This could decrease the effectiveness of phenobarbital (Luminal).

Phenytoin (Dilantin)

Interaction Rating=Moderate Be cautious with this combination.

The body breaks down phenytoin (Dilantin) to get rid of it. Pyridoxine (vitamin B6) might increase how quickly the body breaks down phenytoin. Taking pyridoxine (vitamin B6) and taking phenytoin (Dilantin) might decrease the effectiveness of phenytoin (Dilantin) and increase the possibility of seizures. Do not take large doses of pyridoxine (vitamin B6) if you are taking phenytoin (Dilantin).

Herbs and supplements that might lower blood pressure: Vitamin B6 might lower blood pressure. Taking it with other supplements that have the same effect might cause blood pressure to drop too much. Examples of supplements with this effect include andrographis, casein peptides, L-arginine, niacin, and stinging nettle.

There are no known interactions with foods.

Vitamin B6 is an important nutrient. Cereal grains, legumes, vegetables, meat, and eggs are good sources of vitamin B6. The amount that should be consumed on a daily basis is called the recommended dietary allowance (RDA). For males, the RDA is 1.3 mg daily for those 19-50 years old, and 1.7 mg daily for those over 50 years. For females, the RDA is 1.3 mg daily for those 19-50 years old, and 1.5 mg daily for those over 50 years. While pregnant, the RDA is 1.9 mg daily. While breast-feeding, the RDA is 2 mg daily. In children, the RDA depends on age.

In supplements, vitamin B6 is often used alone and in products containing other B vitamins. Speak with a healthcare provider to find out what type of product and dose might be best for a specific condition.

Adermine Chlorhydrate, Adermine Hydrochloride, B Complex Vitamin, B6, Chlorhydrate de pyridoxine, Complexe de Vitamines B, Phosphate de Pyridoxal, Phosphate de Pyridoxamine, Piridoxina, Pyridoxal, Pyridoxal Phosphate, Pyridoxal 5 Phosphate, Pyridoxal-5-Phosphate, Pyridoxal-5'-Phosphate, Pyridoxamine, Pyridoxamine Phosphate, Pyridoxamine-5'-Phosphate, Pyridoxine, Pyridoxine HCl, Pyridoxine Hydrochloride, Pyridoxine Phosphoserinate, Pyridoxine-5-Phosphate, Pyridoxine-5'-Phosphate, P5P, P-5-P, Vitamin B-6, Vitamina B6, Vitamine B6.

Natural Medicines disclaims any responsibility related to medical consequences of using any medical product. Effort is made to ensure that the information contained in this monograph is accurate at the time it was published. Consumers and medical professionals who consult this monograph are cautioned that any medical or product related decision is the sole responsibility of the consumer and/or the health care professional. A legal License Agreement sets limitations on downloading, storing, or printing content from this Database. Except for any possible exceptions written into your License Agreement, no reproduction of this monograph or any content from this Database is permitted without written permission from the publisher. Unlawful to download, store, or distribute content from this site.

For the latest comprehensive data on this and every other natural medicine, health professionals should consult the Professional Version of the Natural Medicines. It is fully referenced and updated daily.

© Copyright 1995-2021. Therapeutic Research Faculty, publishers of Natural Medicines, Prescriber's Letter, and Pharmacist's Letter. All rights reserved.

trclogo Licensed from Therapeutic Research Center, LLC Copyright © 1995-2023 by Therapeutic Research Center, LLC. All Rights Reserved.